Part 1 Optimizing GH treatment: how do we best measure growth hormone action?, H.J. Guyda; optimizing growth hormone therapy in children, A. Grimberg and P. Cohen; optimizing growth hormone therapy during puberty, E. Codner et al; guidelines for optimizing growth hormone replacement therapy in adults, H. de Boer and E. van der Veen; growth hormone therapy for Turner syndrome - evidence for benefit, J.-C. Carel et al; growth hormone therapy in Turner syndrome - current uncertainties and future strategies, M.D.C. Donaldson. Part 2 GH, sex steroids and the skeleton: the action of GH/IGF-I/IGFBP in osteoblasts and osteoclasts, K. Chihara and T. Sugimoto; markers of bone and collagen metabolism - problems and perspectives in paediatrics, E. Schonau and F. Rauch; skeletal effects of growth hormone and IGF-I in adults, R. Marcus; sex steroids and the acquisition of bone mass, G. Saggese et al; growth hormone and the acquisition of bone mass, G. Johannsson and B.A. Bengtsson; the pathogenesis of osteoporosis, E.F. Eriksen and B.L. Langdahl; the management of acute bone loss in severe catabolism due to burn injury, G.L. Klein et al. Part 3 GH, obesity and lipid metabolism: health consequences of fat distribution, M.D. Jensen; fat distribution in children and adolescents - the influence of sex and hormones, C.T. Cowell et al; somatopause and adiposity, J.O.L. Jorgensen et al; action of growth hormone in adipose tissue, B. Richelsen; the use of stable isotopes to unravel the hyperlipidaemia of adult growth hormone deficiency, D.L. Russel-Jones et al; weight regulation, leptin and growth hormone, R.V. Considine.