Part 1 Basic aspects and clinical relevance of binding proteins in the action of GH and IGF-l: circulating growth hormone binding proteins, R.G. Rosenfeld; the GH receptor and signal transduction, P.A. Kelly et al; insulin-like growth factor binding proteins in the human circulation - a review, R.C. Baxter; hormonal and nutritional regulation of IGF-I and its binding proteins, L.E. Underwood et al; the insulin-like growth factor-l receptor - structure, ligand-binding mechanism and signal transduction, P. De Meyts et al. Part 2 Genetic aspects of growth: rapid nuclear actions of growth hormone, P. Rotwein et al; parental imprinting and the IGF2 gene, T.J. Ekstrom; molecular genetics of growth hormone-releasing factors, K. Chihara et al; molecular basis of familial growth hormone deficiency, L.A. Perez Jurado and J. Argente; laron syndrome - clinical features, molecular pathology and treatment, Z. Laron and B. Klinger. Part 3 Regulation of intrauterine growth: regulation of intrauterine growth - the role of maternal health, C. Lowy; hormonal regulation of fetal growth, D. Evain-Brion; placental transport of nutrients to the fetus, W.W. Hay; outcome of low birthweight, D.J.P. Barker. Part 4 Progress reports: progress report - growth hormone in skeletal dysplasia, N.A. Bridges and C.G.D. Brook; adult growth hormone deficiency, J.O.L. Jorgensen et al.