Part 1 The paradox of GH and obesity: body fat in GH-deficient children and the effect of treatment, M. Wabitsch and E. Heinze; effects of growth hormone on body fat in adults, J.M. Gertner; body fat in laron syndrome patients - effects of insulin-like growth factor 1 treatment, Z. Laron and B. Klinger; the effect of simple obesity on growth and growth hormone, M. Vanoderschueren-Lodeweyckx; growth hormone effects on carbohydrate and lipid metabolism in childhood, P.-F. Bougneres; insulin resistance in growth-hormone-deficient adults, F. Salomon et al. Part 2 Pathophysiology of GH: normal control of growth hormone secretion, M.L. Hartman et al; control of the transcription on the growth-hormone-releasing hormone and somatostatin genes by sex steroids, J. Argente and J.A. Chowen; genetics of growth hormone gene expression, J.S. Parks et al; use of growth hormone and insulin-like growth factor 1 in catabolism that is induced by negative energy balance, D.R. Clemmons; growth hormone and diabetes mellitus. a review of sixty-three years of medical research and a glimpse into the future?, P.H. Sonksen et al; ageing and growth hormone, K.K.Y. Ho and D.M. Hoffman. Part 3 The possible therapeutic use of GH and/or IGF-1: acquired growth hormone resistance in patients with hypercactabolism, J. Bentham et al; effect of human growth hormone insulin-like growth factor 1 on whole-body leucine and estimates of protein metabolism, M.W. Haymond et al; growth hormone and insulin-like growth factors as anabolic therapies for osteoporosis, E.F. Eriksen et al; growth hormone and surgery, A. Revhaug and M. Mjaaland. Part 4 Recent advances in GH research: use of recombinant human growth hormone in children with chronic renal insufficiency - an update, B. Lippe et al; a novel-peptidyl growth hormone secretagogue, K. Cheng et al.