In the summer of 1989, one of us (SLG), along with his mentor, Dorothy Warb- ton, attended the Tenth International Workshop on Human Gene Mapping. The me- ing was held at Yale University in celebration of the first such event, which also took place there. This meeting was not open to the general public; one had to have contributed to mapping a gene to be permitted to attend. The posters, of course, were therefore all related to gene mapping, and many were covered with pretty, colorful pictures of a novel, fluorescent application of an old technology, in situ hybridization. Walking through the room, Dorothy remarked that, because of this new FISH technique, ch- mosomes, which had become yesterday's news, were once again "back in style. " Approximately three years later, a commercial genetics company launched a FISH assay for prenatal ploidy detection. A substantial number of cytogeneticists across the country reacted with a combination of outrage and panic. Many were concerned that physicians would be quick to adopt this newfangled upstart test and put us all on the unemployment line. They did not at the time realize what Dorothy instinctively already knew-that FISH would not spell the doom of the cytogenetics laboratory, but it would, rather, take it to new heights.
Rezensionen / Stimmen
From Reviews of the First Edition... "...an excellent comprehensive review of the basic concepts of clinical cytogenetics...recommended for any medical specialty that utilizes cytogenetic testing." -Modern Pathology "...a good grounding for anyone with a general interest in the subject..." -Human Genetics "...a real contribution to the field...should be a permanent resource not only for cytogeneticists, but also for doctors active in hematology and oncology, clinical pathologists, and perinatal specialists." -Laboratoriums Medezin "...an up-to-date window into the recent advances in cytogenetics, both molecular and clinical...recommended even for those who already have the first edition." - Journal of the Association of Genetic Technologists
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Research
Editions-Typ
Illustrationen
243 s/w Abbildungen, 24 farbige Abbildungen
243 black & white illustrations, 24 colour illustrations
Maße
Höhe: 25.4 cm
Breite: 17.8 cm
Gewicht
ISBN-13
978-1-58829-300-8 (9781588293008)
DOI
Schweitzer Klassifikation
Section I. Basic Concepts and Background
History of Clinical Cytogenetics
Steven L. Gersen
DNA, Chromosomes, and Cell Division
Martha B. Keagle
Human Chromosome Nomenclature: An Overview and Definition of Terms
Avirachan Tharapel
Section II. Examining and Analyzing Chromosomes
Editors' Foreword
Steven L. Gersen and Martha B. Keagle
Basic Laboratory Procedures
Martha B. Keagle and Steven L. Gersen
The Fundamentals of Microscopy
Christopher McAleer
Quality Control and Quality Assurance
Michael Watson and Steven L. Gersen
Instrumentation in the Cytogenetics Laboratory
Steven L. Gersen and Lotte Downey
Section III. Clinical Cytogenetics
Autosomal Aneuploidy
Jin-Chen C. Wang
Structural Chromosome Rearrangements
Kathleen Kaiser-Rogers and Kathleen Rao
Sex Chromosomes and Sex Chromosome Abnormalities
Cynthia M. Powell
Cytogenetics of Infertility
Linda Marie Randolph
Prenatal Cytogenetics
Linda Marie Randolph
Cytogenetics of Spontaneous Abortion
Solveig M. V. Pflueger
Chromosome Instability
Xiao-Xiang Zhang
Section IV Cancer Cytogenetics
Cytogenetics of Hematologic Neoplasms
Rizwan C. Naeem
Cytogenetics of Solid Tumors
Jonathan A. Fletcher
Section V. Fluorescence In Situ Hybridization
Fluorescence In Situ Hybridization (FISH)
Daynna J. Wolff and Stuart Schwartz
Section VI. Beyond Chromosomes
Editors' Foreword
Steven L. Gersen and Martha B. Keagle
Fragile X: From Cytogenetics to Molecular Genetics
Dana C. Crawford and Patricia N. Howard-Peebles
Genomic Imprinting and Uniparental Disomy
Jin-Chen C. Wang
Genetic Counseling
Sarah Hutchings Clark
Index
