This book provides a comprehensive, in-depth explanation of the basic concepts and interpretations involved in chromosome analysis, a critical technique in the diagnosis, prognosis, and monitoring of a wide variety of conditions. Designed for the health care provider who must use and explain the often complex results of these tests, this book details in understandable language the various applications of chromosome analysis in clinical settings and the clinical significance of abnormal results. In addition, the book offers an informative tutorial on basic laboratory procedures (including microscopy, photomicrography, automation, computerized karyotyping, and QA/QC), reports on novel synergistic technologies such as FISH, and discusses issues in genetic counseling. Enlightening and accessible, The Principles of Clinical Cytogenetics constitutes an indispensable reference for today's physicians and managed care practitioners who depend on the cytogenetics laboratory for the diagnosis of their patients' ailments.
Rezensionen / Stimmen
"...this book is a real contribution to the field of cytogenetics, and is scientifically and clinically adept. I should be a permanent resource not only for cytogeneticists, but also for doctors active in hematology and oncology, clinical pathologists, and perinatal specialists."-Laboratoriums Medizin "This book is an excellent document on clinical cytogenetics." - Cellular and Molecular Biology "For those starting out or working in this field, the book would also provide an excellent grounding in the background to the techniques used and the service provided by cytogenetic laboratories."- Human Genetics "...is an essential reference book for all clinical cytogeneticists. It is written with a unique laboratory focus; it answers the most frequently asked questions about chromosomes and chromosomal disease and presents a comprehensive look at the field as it stands today. A careful reading of this book would serve as excellent review for the American Board of Medical Genetics examination...Gersen and Keagle tell the story better than anyone." - The American Society of Human Genetics "...an essential reference book for all clinical cytogeneticists...written with a unique laboratory focus; it answers the most frequently asked questions about chromosomes and chromosomal disease and presents a comprehensive look at the field as it stands today." - The American Society for Human Genetics
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Professional/practitioner
Illustrationen
1
1 farbige Abbildung
1 colour illustrations
Maße
Höhe: 25.4 cm
Breite: 17.8 cm
Gewicht
ISBN-13
978-0-89603-553-9 (9780896035539)
Schweitzer Klassifikation
Part I. Basic Concepts and Background. History of Clinical Cytogenetics, S. L. Gersen. DNA, Chromosomes, and Cell Division, M. Keagle and J. D. Brown. Human Chromosome Nomenclature: An Overview and Definition of Terms, A. Tharapel. Part II. Examining and Analyzing Chromosomes. Basic Laboratory Procedures,
M. B. Keagle and S. L. Gersen. Microscopy and Photomicrography, C. McAleer. Quality Control and Quality Assurance, C. McAleer and S. L. Gersen. Automation in the Cytogenetics Laboratory, S. L. Gersen and J. Ginestet. Part III. Clinical Cytogenetics. Autosomal Aneuploidy, J.-C. C. Wang. Structural Chromosome Rearrangements, K. Kaiser-Rogers and K. Rao. Sex Chromosomes and Sex Chromosome Abnormalities, C. M. Powell. Prenatal Cytogenetics, L. M. Randolph. Cytogenetics of Spontaneous Abortion, S. M. V. Pflueger. Cancer Cytogenetics, A. W. Block. Part IV. Beyond Chromosomes. Fragile X: From Cytogenetics to Molecular Genetics, P. N. Howard-Peebles. Fluorescence In Situ Hybridization, J. K. Blancato. Genomic Imprinting and Uniparental Disomy, J.-C. C. Wang. Genetic Counseling, Y. Furman. Index.
