Statistics and Experimental Design for Toxicologists has been designed as both a sourcebook for the practicing toxicologist and a textbook for the student toxicologist. Its function is to provide both with tools for the rigorous and critical analysis of experimental data. Assuming only basic mathematical skills, the volume provides a complete and exhaustive introduction to the statistical methods available to and used in the discipline. For each technique presented, a practical example is provided and a collection of problems is also included, together with appendices containing the necessary tables of test values.
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Höhe: 229 mm
Breite: 152 mm
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978-0-936923-17-8 (9780936923178)
Schweitzer Klassifikation
INTRODUCTION. Philosophy and General Principles. Overview. BASIC PRINCIPLES. Types of Data. Functions of Statistics. Descriptive Statistics. Sampling. Outliers and Rounding. Decision Trees for Methods. EXPERIMENTAL DESIGN. Objectives. General Principles. Approaches for Toxicology. Logistical and Planning Tools. Necessary Sample Sizes. COMPUTATIONAL DEVICES. Calculators. Microcomputers and Software. Statistical Libraries. METHODS FOR DATA PREPARATION AND EXPLORATION. Randomization. Bartlett's Test. Scattergram. Exploratory Data Analysis. HYPOTHESIS TESTING: CATEGORICAL AND RANKED DATA. Fisher's Exact Test. RXC ChiSquare. Wilcoxon Rank-Sum Test. Distribution-Free Multiple Comparisons. Mann-Whitney U Test. Kruskal-Wallis Nonparametric Analysis of Variance. HYPOTHESIS TESTING: UNIVARIATE. Student's t-Test. Cochran's t-Test. F-Test. Analysis of Variance. Post-Hoc Tests. Duncan's Multiple Range. Scheffe's Multiple Comparisons. Dunnett's t-Test. William's t-Test. Analysis of Covariance. MODELING. Linear Regression. Probit. Log Plots. Moving Averages. Correlation Coefficient. Nonlinear Regression. Kendall's Rank Correlation. Trend Analysis. METHODS FOR THE REDUCTION OF DIMENSIONALITY. Classification. Construction of Tables. Statistical Graphics. Multidimensional and Nonmetric Scaling. Cluster Analysis. Fourier Analysis. Life Tables. MULTIVARIATE METHODS. Multivariate Distribution and Population Parameters. Data Preparation. MANOVA. Factor Analysis. Multiple Regression. Discriminant Analysis. Canonical Correlation Analysis. Principal Components. Correspondence Analysis. Biplot Analysis. DATA ANALYSIS APPLICATIONS IN TOXICOLOGY. LD50 and LC50. Body and Organ Weights. Clinical Chemistry. Hematology. Histopathology. Reproduction. Teratology. Dominant Lethal. Diet and Chamber Analysis. Aerosol Statistics. Mutagenesis. Behavioral Toxicology. CARCINOGENESIS AND RISK ASSESSMENT. Analysis of Carcinogenicity Bioassay. Low Dose Extrapolation. STRUCTURE ACTIVITY RELATIONSHIPS. AREAS OF CONTROVERSY. One or Two Sided Comparisons. Unbalanced Study Designs. Computerized Statistical Packages. APPENDICES. Logarithms. Probit Transform Values. Chi Square. H Values. Mann-Whitney U Values. t-Test Critical Values. F Distribution. Z Scores for Normal Distribution. Table for Calculation of Median Effective Dose by Moving Average. Critical Values for the Wilcoxon Rank-Sum Test. Definition of Terms. Greek Alphabet, Abbreviations and Symbols. Index. 376 pp., 1988, ISBN 0-936923-17-2.
