The papers collected in this volume were presented at the 5th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Rimini, Italy, in June 1978. This meeting was organized by the Italian Group for Mass Spectrometry in Biochemistry and Medicine, which was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). I wish to thank Mrs. Anna Bernard, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless eff. orts in the preparation of this volume. Alberto Frigerio Milan, March, 1979 v Contents The Place of Mass Spectrometry in Drug Metabolism Studies ...1 A. Benakis In Vitro and in vivo Studies on the Metabolism of Dibenzo/c,f 7-/-1,2 7 Diazepine ********. ********* 9 A. Frigerio, P~ Negrini, D~ Rotilio, A. De Pascale and E. Rossi Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat 27 L. Simonotti, R. Colombo and G. Pifferi Mass Spectrometric Characterization of Sydnocarb ~ and its Major Metabolites in Rat ***************** 43 J. Tamas, M. Polgar, G. Czira and L.
Vereczkey Metabolism of an Aryloxy Beta Blocking Drug 53 G. L. Passetti, E. Grassi and A. Trebbi Isolation and Identification of the Chloroform Soluble Urinary Metabolites of Suloctidil in Man . ****. . ** 69 R. Roncucci, W. Cautreels, M. Martens, C. Gillet, K. Debast and G. Lambelin Are Stable Sulfenic Acids Possible Metabolites of Suloctidil? ...85 W. Cautreels, M. Martens, R. Roncucci, C. Gillet, K. Debast and G.
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978-0-306-40294-4 (9780306402944)
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The Place of Mass Spectrometry in Drug Metabolism Studies.- In vitro and in Vivo Studies on the Metabolism of Dibenzo [c,f]--[1,2] Diazepine.- Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat.- Mass Spectrometric Characterization of Sydnocarb (R) and its Major Metabolites in Rat.- Metabolism of an Aryloxy Beta Blocking Drug.- Isolation and Identification of the Chloroform Soluble Urinary Metabolites of Suloctidil in Man.- Are Stable Sulfenic Acids Possible Metabolites of Suloctidil?.- The Electron Impact Fragmentation of Products Related to N-(Allyl)-3,3-Diphenylpropylamine, a Metabolite from Thiopropamine (R).- Urinary Metabolites from (2-Ethyl-2,3-Dihydro-5-Benzofuranyl) Acetic Acid.- The Major Metabolites of Niclosamide: Identification by Mass Spectrometry.- The Metabolism of Deuterium-Labelled Analogues of ?1-, ? 6-, and ? 7-Tetrahydrocannabinol and the Use of Deuterium Labelling.- Kinetics of Degenerate Nucleophilic Exchange of C(3)-Hydroxy Group in l-Methyl-3-Hydroxy- -5-Phenyl-7-Cloro-2H-l,4-Benzodiazepin-2-One.- On the Analysis of Fermentation Broth During Biosynthesis of Cephalosporin Antibiotics.- GC-MS Analysis by Electron Impact Ionization and Chemical Ionization of Carcinogenic 2-Acetylaminofluorene and its Metabolites.- The Proximo-Distal Carcinogen of the K Region of Benzo (a)Pyrene.- Quantitative Determination of Vincamine in Human Plasma by Gas Chromatography - Mass Spectrometry.- Mass Fragmentographic Quantification of Phosphonoacetic Acid in the Blood of Monkeys Infected with Herpesvirus Saimiri.- The Determination of Blood Cyanide and Plasma Thiocyanate by Gas Chromatography-Mass Spectrometry.- Present State and Future Trends of Negative Ion Mass Spectrometry in Toxicology, Forensic and Environmental Chemistry.- Mass Fragmentographic Determination of Polyamines in the Urine of Premature Babies.- An Assay for Schizophrenia: Mass Spectrometric Determination of Two Cadaverine Metabolites.- Analysis of the Urinary Steroids from a Pathological Pregnancy by Liquid-Gel Chromatography and Gas-Chromatography-Mass Spectrometry.- Identification of Atypical Bile Acids by Gas Chromatography-Mass Spectrometry-Computer Techniques.- The Effects of Triisopropylacetic Acid on the Metabolic Profile of Urinary Organic Acids.- Application of Chemical Ionization MS to the Study of Regional Brain Catecholamine Metabolism in (S)-?-Methyldopa Treated Rats.- Concurrent Extraction and GC-MS Assay of Endogenous TP, T, IAA, 5HT and 5HIAA in Single Rat Brain Samples.- A New Method for Simplified Prostaglandin Profiling by Selected Ion Monitoring.- Analysis of Urinary Steroids by Liquid-Gel Chromatography and Gas Chromatography - Mass Spectrometry. Clinical Applications.- A Micromethod for the Clinical Chemistry Routine Analysis of Amino Acids in Blood and Urine by Capillary Gas Liquid Chromatography of Isobutyl Esters N(O)-Heptafluorobutyrate Derivatives.- Metabolic Profile of Ventricular Cerebrospinal Fluids.- Energy and Metastable Characteristics in Peptides, Electron Impact Appearance Potentials of Sequence Ions in Tripeptides.- The Continuous Recording of Expired C16O18O by Respiratory Mass Spectrometry After Injection of H218O into the Vascular System.- A Continuous Mass Spectrometric Analysis of Expired Physiological Gases: the Pulmonary Gas Exchange.- Adaptation of Respiratory Mass Spectrometer to Continuous Recording of Abundance Ratios of Stable Oxygen Isotopes.- The Development of a Flexible Mass Spectrometer Catheter.- Contributor Index.
