The papers collected in this volume were presented at the 4th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Riva del Garda, Italy in June 1977. This meeting was organised by the Italian Group for Mass Spectrometry in Biochemistry and Medicine. The group was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). The aim of the symposium was to bring together people working in different branches of mass spectrometry for mutual discussion, exchange of ideas and experience. I wish to thank Mrs. Judy Baggot, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless efforts in the preparation of this volume. Alberto Frigerio Milan, January, 1978 v CONTENTS Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites * * * * 1 W. J. Richter, P. Kriemler and J. W. Faigle Distribution in Brain Areas of Carbamazepine and Carbamazepine-lO,ll-epoxide in 6-Hydroxydopamine Pretreated Rats 15 C. Pantarotto, V. Crunelli, A. Quattrone, P. Negrini, A. Frigerio and R.
Samanin Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations- Applications to Alprenolol in Rats and Dogs 29 T. Walle and K. Walle The Use of GC-MS in Perinatal Pharmacology: The Metabolism and Pharmacokinetics of Analgesic Drugs in Mothers and Their Babies * * * * * * * * 49 J. Caldwell, L. J. Notarianni and L. A.
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Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites.- Distribution in Brain Areas of Carbamazepine and Carbamazepine-10,11-epoxide in 6-Hydroxydopamine Pretreated Rats.- Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations-Applications to Alprenolol in Rats and Dogs.- The Use of GC-MS in Perinatal Pharmacology: The Metabolism and Pharmacokinetics of Analgesic Drugs in Mothers and Their Babies.- Studies on the Measurement of ?-Methyldopa in Pregnant Women and the Newborn Infant.- Gas Chromatography-Mass Spectrometry Identification of Some Urinary Metabolites of Thiopropamine, a New Antiulcer Agent.- Metabolism and Pharmacokinetics of Bromopride in Rat and Man.- GC and MS in the Identification of Metabolites of 5-(1-methylethyl)-1-methyl-2-nitro-l H-imidazole in Dogs.- Isolation and Identification of Oxidized Metabolites of Phenazopyridine from Rat Urine.- The GC-MS Analysis of Unchanged Suloctidil (sulocton (R)) in Plasma and Urine.- Direct Quantification of Apovincaminic Acid Ethyl Ester (cavinton (R)) in Human Plasma and Urine by Mass Fragmentography.- A Mass Fragmentographic Method for the Determination of Mescaline in Biological Fluids.- Comparative in vivo Metabolism of ?1-tetrahydrocannabinol (?1-THC), cannabidiol (CBD) and cannabinol (CBN) by Several Species.- Chemical Ionization Techniques for the Analysis of Labile Compounds: 1,3-bis-(2-chloroethyl)-1-nitrosourea Plasma Clearance and Degradation.- Metabolic Profile of Biological Constituents: (1) the Effects of Sodium Dipropylacetate on Human Urinary Acids.- Investigation of Unusual Metabolites in the Urine of a Patient with Propionic Acidemia.- Identification and Quantification of Gamma-Aminobutyric Acid in Human Cerebrospinal Fluid by Gas Chromatography- Mass Spectrometry.- A New Derivatization Approach for the Determination of Prostaglandin A1 by Mass Fragmentography.- The Use of Stable Oxygen Isotopes and Mass Fragmentography for Assessing Enzyme Activity: Phenylalanine Hydroxylase in vivo.- Brain Monoamines, Monoamine Metabolites and Enzymes in Physiological Ageing and Senile Dementia.- Ontogenic Variation of Dopamine and Norepinephrine in the Adrenal Medulla of Developing Rat. A Study by Mass Fragmentography.- Quantitation of Total Urinary N-acetylcysteine Conjugates (Mercapturic Acids) by Selected Ion Monitoring.- Quantitative Analysis of Blood Amino Acids and Fatty Acids by Direct Mass Spectrometry.- Blood Levels of Cadaverine and its Metabolites Monoacetylcadaverine and Monopropionylcadaverine in Psychotic Subgroups of Schizophrenics.- Quantitative Analysis of Free and Bound Cholesterol and Cholesterol Ester Fatty Acids in Blood by Direct Mass Spectrometry.- New Developments in the Field of Mass Spectrometry and GC-MS and Their Applications to Toxicological Analysis.- In situ Methylation and/or FD-MS: A Comparative Study of Their Usefulness in the Structure Analysis of Highly Polar Metabolites.- The Exchange of Trideuteromethyl Groups When Using Methane as a Reagent Gas in Chemical Ionisation Mass Spectrometry.- Controlled Thermal Degradation Mass Spectrometry. A Direct Approach for the Analysis of Biological and Synthetic Polymers.- Comparison of Library Search Methods with Binary Encoded Steroid Mass Spectra.- Fragmentation of Monosubstituted Cyclopentenes Under Electron Impact Mass Spectrometry.- Mass Spectrometric Investigations of Stereoisomeric 3-Substituted Tropane Derivatives.- Cyclic Alkoxythiobenzamides. Mass Fragmentation and Rearrangement Under Electron Impact.- Fragmentation of Piperazinodibenzazepines on Electron-Impact.- Isolation and Determination of Structures of Some New Diterpenoid Alkaloids in Delphinium ajacis by Mass Spectrometry.- Mass Spectrometric Studies of Algal Sterols Using an Open Tubular Capillary Column.- Open Tubular Capillary Column Gas Chromatography- Mass Spectrometry of Cholecalciferol and Its Active Metabolites.- Mass Spectral Fragmentation of C5-Substituted Barbituric Acid Derivatives.- The Mass Spectra of Permethylated Disaccharides.- Quanititative Determination of Unconjugated Pterins in Biological Extracts by Gas Chromatography-Mass Fragmentography.- Mass Spectrometry of Sialic Acids.- Direct Evidence of Epoxide Metabolic Pathway for Natural Allylbenzene Compounds in Adult Rat Liver Cell Culture.- Identification and Quantitative Determination of 2,3,7,8-Tetrachlorodibenzo-para-dioxin in Animals From a Contaminated Area.- Structure Elucidation on Hydroxylated Metabolites of Polychlorinated Aromatic Compounds by GC-MS Investigation of Their Methyl Ethers.- Detection of Polychlorodibenzodioxins in Fly Ash and Flue Gas of Municipal Incinerators.- 2,3,7,8 TCDD Monitoring in Flue Gases from an Incinerating Plant.- A Peripherally Inserted Flow Directed Catheter for Use in Continuously Monitoring Pulmonary Artery Oxygen and Carbon Dioxide Tensions.- The Effect of Acute Alkalosis on Intrahepatic Oxygen Tension as Measured in Bile.- Medical Mass Spectrometry in Simultaneous Measurement of Respiratory and Blood Gases.- Measurements of Whole Body Protein Turnover in Man with 15N-glycine.- 15N Abundance in N-Fixing and Non-N-Fixing Plants.- Isotope Effects in Metabolic Studies.- Participants.- Author Index.
