Table of Contents
Part 1. Sources and Consequences of DNA Damage
1. Introduction: Biological Responses to DNA Damage
2. DNA Damage
3. Introduction to Mutagenesis
Part 2. Correcting Altered Bases in DNA: DNA Repair
4. Reversal of Base Damage Caused by UV Radiation
5. Reversal of Alkylation Damage in DNA
6. Base Excision Repair
7. Nucleotide Excision Repair: General Features and the Process in Prokaryotes
8. Nucleotide Excision Repair in Eukaryotes: Cell Biology and Genetics
9. Mechanism of Nucleotide Excision Repair in Eukaryotes
10. Heterogeneity of Nucleotide Excision Repair in Eukaryotic Genomes
11. Alternative Excision Repair of DNA
12. Mismatch Repair
13. Repair of Mitochondrial DNA Damage
Part 3. DNA Damage Tolerance and Mutagenesis
14. The SOS Responses of Prokaryotes to DNA Damage
15. Mutagenesis and Translesion Synthesis in Prokaryotes
16. Recombinational Repair, Replication Fork Repair, and DNA Damage Tolerance
17. DNA Damage Tolerance and Mutagenesis in Eukaryotic Cells
18. Managing DNA Strand Breaks in Eukaryotic Cells: Repair Pathway Overview and Homologous Recombination
19. Managing DNA Strand Breaks in Eukaryotic Cells: Nonhomologous End Joining and Other Pathways
Part 4. Regulatory Responses to DNA Damage in Eukaryotes
20. Cell Cycle Checkpoints: General Introduction and Mechanisms of DNA Damage Sensing
21. Cell Cycle Checkpoints: Signal Transmission and Effector Targets
22. Transcriptional Responses to DNA Damage
23. DNA Damage and the Regulation of Cell Fate
Part 5. Disease States Associated with Defective Biological Responses to DNA Damage
24. Xeroderma Pigmentosum: a Disease Associated with Defective Nucleotide Excision Repair or Defective Translesion DNA Synthesis
25. Other Diseases Associated with Defects in Nucleotide Excision Repair of DNA
26. Diseases Associated with Defective Responses to DNA Strand Breaks
27. Diseases Associated with Disordered DNA Helicase Function
28. Additional Diseases Associated with Defective Responses to DNA Damage
29. Hereditary Diseases that Implicate Defective Responses to DNA Damage
30. DNA Polymorphisms in Gatekeeper and Guardian Genes
Appendix
Table 1. Nomenclature of DNA repair genes
Table 2. Human hereditary diseases and defective cellular responses to DNA damage
