In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.
Reihe
Auflage
Softcover Reprint of the Original 1st 2011 ed.
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Illustrationen
Maße
Höhe: 235 mm
Breite: 155 mm
Dicke: 31 mm
Gewicht
ISBN-13
978-3-662-50230-3 (9783662502303)
DOI
10.1007/978-3-642-13443-2
Schweitzer Klassifikation
From the contents: Brief history of methylxanthine use. Distribution of methylxanthines in plants with comments on possible evolutionary origins. Pharmakokinetics and metabolism of natural methylxanthines in animals and man. Phosphodiesterase inhibition. Ryanodine receptors and calcium. Adenosine receptor antagonism. Theobromine and the pharmacology of cocoa. Pentoxifylline. Propentofylline. Methylxanthines, seizures and excitotoxicity. Methylxanthines and neurodegenerative disease. Methylxanthines and pain. Methylxanthines during pregnancy and early postnatal life. Methylxanthines and sleep. Methylxanthines and the kidney. Cardiovascular effects of methylxanthines. Methylxanthines in asthma. Methylxanthine effects on inflammatory cells. Methylxanthines, inflammation and cancer. Methylxanthines and drug dependence. Methylxanthines and reproduction. Methylxanthines and human health. Epidemiological and experimental evidence.
