Congenital heart disease: an epidemiologic and teratologic challenge; Research design, resources and methods; Infants with congenital heart disease: the cases; Study subjects: participant rates and representativeness; Data collection: methods and quality control; Preparing the database and creating the variables; The genetics of congenital heart disease; Maternal medical, anthropometric and reproductive characteristics; Prescription and non-prescription drugs; Lifestyle: cigarettes, alcohol, recreational drugs and caffeine; Environmental factors in occupations, home and hobbies; Risk factor analysis; Overview and research implications