Epidemiological aspects; methods for the study of human metabolism in vivo; insulin secretion; insulin resistance; energy metabolism; endogenous glucose production in obesity and NIDDM; obesity and lipid metabolism; obesity and carbohydrate metabolism; obesity and diabetes; evolution from obesity to diabetes; protein metabolism; associated cardiovascular morbidity; prevention and therapeutics - physiopathological considerations, epidemiological and public health considerations; time - duration of evolution, succession of events and alternance of synthesis and mobilization of substrates and hormones; concluding remarks.
