A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.
Rezensionen / Stimmen
"This book will certainly be a very useful reference work for the practicing adult haematologist." - Pediatric Hematology Oncology
Reihe
Auflage
Softcover reprint of hardcover 1st ed. 2004
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Professional/practitioner
Illustrationen
Maße
Höhe: 254 mm
Breite: 178 mm
Dicke: 24 mm
Gewicht
ISBN-13
978-1-61737-355-8 (9781617373558)
DOI
10.1007/978-1-59259-412-2
Schweitzer Klassifikation
I. Introduction.- 1 The Natural History of CLL: Historical Perspective.- II. Biology and Genetics.- 2 Genetics of B-Cell Chronic Lymphocytic Leukemia.- 3 Molecular Biology of Chronic Lymphocytic Leukemia.- 4 The Heterogeneous Origin of the B-CLL Cell.- 5 Pathogenesis of Impaired Cellular Immune Function in CLL.- 6 Cytokines and Soluble Molecules in CLL.- III. Clinical Aspects: Diagnosis.- 1 Immunophenotypic Differential Diagnosis and Cell Cycle Analysis.- 8 Common Cytogenetic Abnormalities.- 9 Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia.- IV. Clinical Aspects: Prognosis.- 10 Staging of Chronic Lymphocytic Leukemia.- 11 Prognostic Indicators of Chronic Lymphocytic Leukemia.- V. Clinical Aspects: Treatment.- 12 Guidelines for Clinical Management of CLL.- 13 Chemotherapy of Chronic Lymphocytic Leukemia.- 14 Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia.- 15 Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia.- 16 Immunotoxin Therapy of Chronic Lymphocytic Leukemia.- 17 New Treatment Strategies in Chronic Lymphocytic Leukemia.- 18 Gene Therapy of Chronic Lymphocytic Leukemia.- VI. Clinical Aspects: Complications.- 19 Infections in Patients With Chronic Lymphocytic Leukemia.- 20 Autoimmune and Hypersplenic Cytopenias.- 21 Clonal Evolution and Second Malignancies in B-CLL.- VII. Familial and Juvenile Chronic Lymphocytic Leukemia.- 22 Inherited Predisposition to Chronic Lymphocytic Leukemia.- 23 Young Patients With Chronic Lymphocytic Leukemia.
