Liver transplantation in dogs preceded, in the early sixties, the first clinical liver transplantation. Thereafter, the pig was used by many surgeons. The last ten years has been the decade of the rat, since the development of proper microsurgical techniques enabled many scientists to use especially inbred animals for their studies. Clinical liver transplantation is therefore being pushed forward to new and safer immunosuppressive protocols. The chapters in this book follow the schedule of the scientific meeting, highlighting some interesting new results and aspects in cellular transplantation, as well as immunology in its pure analytical sense, and clinical immunosuppression. The volume will no doubt help improve the results of clinical liver transplantation.
Liver transplantation in dogs preceded, in the early sixties, the first clinical liver transplantation. Thereafter, the pig was used by many surgeons. The last ten years has been the decade of the rat, since the development of proper microsurgical techniques enabled many scientists to use especially inbred animals for their studies. Clinical liver transplantation is therefore being pushed forward to new and safer immunosuppressive protocols. The chapters in this book follow the schedule of the scientific meeting, highlighting some interesting new results and aspects in cellular transplantation, as well as immunology in its pure analytical sense, and clinical immunosuppression. The volume will no doubt help improve the results of clinical liver transplantation.
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Elsevier Science & Technology
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Für höhere Schule und Studium
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ISBN-13
978-0-444-81375-6 (9780444813756)
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Schweitzer Klassifikation
PATHOLOGY OF REJECTION. The expression of donor MHC antigens in rejecting allografts. The histopathological classification of liver allograft rejection. Histological diagnosis of rejection, therapeutical consequences and outcome after liver transplantation. Diagnostic features of early postoperative liver allograft rejection. Acute liver graft rejection: Correlation between morphological and clinical diagnosis. Phenotypic and functional study of graft infiltrating cells in rat liver transplantation. The value of fine needle aspiration biopsy for monitoring liver function and rejection after auxiliary segmental liver transplantation in the dog. VIRAL INFECTIONS. Prevention of hepatitis B virus recurrence in liver transplant recipients by passive immunization. Hepatitis B virus infection and liver transplantation -What if passive immunization fails? The occurrence of antibodies against hepatitis C virus in 49 liver transplant patients. Cytomegalovirus infection after liver transplantation: Incidence and clinical outcome. PRESERVATION. Experience with preservation solution (Bretschneider) in orthotopic liver transplantation in the pig. Intrahepatic shunt volume predicts graft function after liver transplantation in pigs. Development of organ edema during organ perfusion and protection -The comparison between Euro-Collins, UW-solution and HTK-solution. Results of experimental liver transplantation in the minipig with HTK preserved organs. The importance of reduced glutathione in the UW solution for liver preservation. Histological evidence of reperfusion injury in rat liver. Liver cell preservation studies using hepatocyte culture. Measurement of the metabolic state of liver tissue by laser-induced surface florescence on acute liver ischemia with radical scavenger protection. Ion-selective measurement and its application in organ preservation: Preliminary results in porcine pancreas transplanatation. HEPATOCELLULAR TRANSPLANTATION, IMMUNOGENICITY. Critical reflections on clinical indications and results of hepatocellular transplantation. Hepatocyte transplantation: Prognosis for a clinical future. Allo- and xenotransplantation of liver microfragments in rats. HLA and liver transplantation. Role of allo-reactive lymphocytes, biliary epithelial and vascular endothelial cells in liver transplantation. The influence of class I and II antigens on the development of graft tolerance after rat liver transplantation. Soluble class I molecules inhibit alloreactive CTL: Potential role in suppression of organ rejection. IMMUNOLOGY. Introduction. Cell-mediated suppression of transplant rejection. Increased frequency of CD45RO+ CD45RA- "memory" T cells in patients with acute rejection after liver transplantation. The role of natural killer cells in allograft survival in rats. Differential effects of chenodeoxy and ursodeoxycholic acids on allogenic immune response.
