This volume is a one-source guide to the most current information about
red blood cell formation and the action of recombinant human
erythropoietins. Topics in the fields of erythropoiesis, recombinant
protein discovery and production, and treatment of patients with anemia
will be covered. The newest theories in erythropoiesis (receptors,
signaling), manufacturing, new formulations, and clinical research
are...
Reihe
Auflage
2nd, revised and extended ed. 2009
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für Beruf und Forschung
Research
Editions-Typ
Illustrationen
Maße
Höhe: 24.4 cm
Breite: 17 cm
Gewicht
ISBN-13
978-3-7643-8694-8 (9783764386948)
DOI
10.1007/978-3-7643-8698-6
Schweitzer Klassifikation
Background.- Erythropoiesis: an overview.- Regulation of endogenous erythropoietin production.- Biology of erythropoietin.- Erythropoiesis-genetic abnormalities.- Erythropoiesis-stimulating agents.- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin.- Commercial production of recombinant erythropoietins.- Biosimilar epoetins.- New molecules and formulations.- Erythropoietin receptor.- Structural basis for the signal transduction of erythropoietin.- Intracellular signaling by the erythropoietin receptor.- Mechanism of erythropoietin receptor activation.- Clinical utility.- Pharmacokinetics of erythropoiesis-stimulating agents.- Use of erythropoietic stimulating agents in the setting of renal disease.- Abuse of recombinant erythropoietins and blood products by athletes.- Role and regulation of iron metabolism in erythropoiesis and disease.- Nonhematopoietic effects of erythropoiesis-stimulating agents.
