The concentration of zinc has been shown to be altered in an extensive number of disorders of the central nervous system, including Alzheimer-type dementia, Down's syndrome, epilepsy, Friedreich's ataxia, multiple sclerosis, Parkinson's disease, schizophrenia, and alcoholism. The role of zinc metallothionein and other low-molecular-weight zinc-binding proteins in these conditions is currently being defined. Since several of these disorders are associated with oxidative stress, and since metallothionein is able to prevent the generation of free radicals, it is believed that cytokine-induced induction of metallothionein provides a long-lasting protection to avert oxidative damage. These topics are extensively discussed in the articles in this volume. Neuroanatomists, neurobiologists, neurochemists, neuropharmacologists, neurologists and psychiatrists will find this state-of-the-art publication a valuable addition to their libraries.
Sprache
Verlagsort
Zielgruppe
Illustrationen
17 Schaubilder, 2 Tabellen
17 figs., 2 tab.
Maße
Höhe: 25.2 cm
Breite: 17.7 cm
Gewicht
ISBN-13
978-3-8055-6057-3 (9783805560573)
Schweitzer Klassifikation
Localization of metallothionein in the mammalian central nervous system, H.G.T. Blaauwgeers et al; metallothionein in developing human brain, K. Suzuki et al; metallothionein in amyotrophic lateral sclerosis, P.A.E. Sillevis Smitts et al; brain metallothionein in stress, J. Hidalgo et al; growth-inhibitory factor, metallothionein-like protein, and neurodegenerative diseases, Y. Uchida.
