Magnetic Resonance Spectroscopic Imaging of Metabolism and pH for Tumor Characterization In Vivo using Hyperpolarized 13C-labelled Biosensors

In this work, changes in tumor perfusion, cancer metabolism, necrosis formation and tumor pH are investigated by a combination of existing and novel methods from Nuclear Magnetic Resonance (NMR), Carbon Magnetic Resonance Spectroscopic Imaging (13C-MRSI) and Dynamic Nuclear Polarization (DNP). The results underline the importance of continuously expanding the number of available imaging methods for a more precise and comprehensive tumor characterization and earlier therapy response evaluation with the aim of selecting, monitoring and individualizing cancer therapies.