This volume deals with the emerging role of complex genetic factors in the pathogenesis of common diseases. These diseases include hypertension, diabetes, obesity, and cancer, and cause a large fraction of morbidity and death. Complex genetic factors are difficult to study in humans, and this book will give the reader a concises view of the major experimental models of polygenic inheritance of predisposition to diseases. It emphasizes the use of models as tools for understanding the basis of the complex genetics of human diseases. This publication can be used as both a reference tool and as a textbook for specialized university courses. it should be of interest to those involved in basic research in animal genetics. molecular genetics, human genetics, and medicine.
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
5 halftones, 1 colour illustration, 15 line drawings, 21 tables
Gewicht
ISBN-13
978-90-5702-336-1 (9789057023361)
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Schweitzer Klassifikation
Models of human monogenic and polygenic disorders in the laboratory mouse; transgenic and knockout models of human polygenic diseases; analysis of physiologic effects of blood pressure and other QTL in congenic diabetes-prone rats; determining quantitative trait loci for blood pressure in the rat - implication for human genetic hypertension; mouse models of human overweight; genetic analysis of murine models for multiple sclerosis; neurotransmitter receptor knockouts - insights into behaviourial traits; polygenic inheritance of melanoma in xiphophorus; polygenic control of susceptibility and resistance to hepatocarcinogenesis; lung cancer in mice - a complex genetic disease; genetics of intestinal carcinogenesis in apemen mice; new approaches in genotyping and mapping.
