The author describes how knowledge of blood pressure control by the brain has advanced during the last quarter of a century. He anatomizes defects in the current theories of causation of hypertension, and discusses hypertension in various genetic rat models, giving reasons for believing that the study of inbred rats does not help to find the cause of hypertension in humans. The author develops his hypothesis in detail, and follows this through with an up-to-date account of the functional organization of the brain stem vasomotor and respiratory centres, their multitude of specific neurotransmitters and interconnections and their blood supply. The bibliography contains nearly 1500 references. There is a supplementary index of all authors quoted. This book should be of interest to physicians and researchers interested in hypertension and physiology.
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
Maße
Höhe: 198 mm
Breite: 252 mm
Gewicht
ISBN-13
978-0-412-39630-4 (9780412396304)
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Schweitzer Klassifikation
Part 1 Theoretical considerations: critical review of previous theories of essential hypertension; inbred rat models for essential hypertension; requirements of a successful hypothesis - the necessity for a comparator and "reference" pressure; construction of a neurogenic hypothesis to explain essential hypertension. Part 2 Control of circulation and respiration by the brain: control of blood pressure by the brain - vasometer centre organization; the anatomy and functional organization of the respiratory centres in the brain stem; the blood supply of the brain stem in animals and man - the nature of the cerebrovascular resistance in normal animals and in experimental and essential hypertension - cerebal autoregulation; the cushing reflex - physiological or pathological. Part 3 Clinical and pathological evidence relevant to the hypothesis: evidence for abnormalities of the central nervous system in essential hypertension - the measurement of sympathetic nervous activity in man; cerebrovascular pathology in essential hypertensions - large artery atheroma; changes in small arteries and arterioles; heredity and environment - the epidemiology of hypertension and atheroma, age of consent, influence of weight; treatment - its relation to the hypothesis and to the occurrence of strokes; renal factors in blood pressure regulation - relationship between the kidneys and the brain; the relation between essential hypertension and heart failure. Part 4 Predictions and conclusions: predictions of the hypothesis; summary - conclusions - the historical perspective.
