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Contributors
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Series Foreword
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Preface
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Acknowledgments
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I.
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Epidemiology, Screening, and Diagnosis
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1 Introduction: The Multidisciplinary Approach to Prostate Cancer
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Leonard G. Gomella
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2.1 Epidemiology of Prostate Cancer
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Kathryn M. Wilson
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Lorelei A. Mucci
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2.2 Diet and Prostate Cancer
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James R. Marshall
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2.3 Epidemiology: Obesity as a Risk Factor
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Emma H. Allott
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Stephen J. Freedland
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3.1.1 Screening and Diagnosis: The Pros of PSA Screening
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Janine L. Oliver
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Gurdarshan S. Sandhu
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Gerald L. Andriole
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Robert L. Grubb III
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3.1.2 The Argument Against Prostate Cancer Screening
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Otis W. Brawley
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3.1.3 How Do We Improve PSA Accuracy?
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Toru Sugihara
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Michael W. Kattan
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3.2 Screening and Diagnosis: An Update on the ISUP-Modified Gleason Score and Its Controversies
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Ibrahim Kulac
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Angelo M. DeMarzo
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3.3 Evaluation of Distant Disease: The Utility of Nuclear Imaging
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Dima Raskolnikov
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Baris Turkbey
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Liza Lindenberg
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Peter L. Choyke
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Peter A. Pinto
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4 Current Approaches to Prostate Cancer Staging and Risk Stratification: In the Midst of a Paradigm Shift
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Chad A. Reichard
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Eric A. Klein
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5.1 Novel Molecular and Genotype Profiling in Prostate Cancer: The Future of Screening, Diagnosis, and Staging
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Heesun Shin
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Ismael A. Vergara
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Anirban P. Mitra
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Timothy J. Triche
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Elai Davicioni
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5.2 Genomics and Risk Assessment
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Hao G. Nguyen
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Matthew R. Cooperberg
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Peter R. Carroll
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5.3 Future Direction: Novel Urine and Serum Markers
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Waleed A. Hassen
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5.4 Morphometric and Systems Pathology: The Future of Screening, Diagnosis, and Staging
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Michael J. Donovan
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Faisal M. Khan
Richard Scott
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Gerardo Fernandez
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Carlos Cordon-Cardo
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5.5.1 PET: The Future of Screening, Diagnosis, and Staging for Prostate Cancer
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Mathew L. Thakur
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Edouard J. Trabulsi
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Sung M. Kim
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Charles M. Intenzo
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Leonard G. Gomella
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5.5.2 DCE MRI and MR Spectroscopy: The Future of Screening, Diagnosis, and Staging
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Victor Sai
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Antonio C. Westphalen
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5.5.3 Future Direction: Contrast Ultrasound 109
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Sanjay Kasturi
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Edouard J. Trabulsi
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Ethan J. Halpern
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6 Counseling Patients With Clinically Localized, High-Risk Prostate Cancer
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Jonathan L. Silberstein
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James A. Eastham
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II.
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Treatment for Low-Risk, Localized Disease
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7 Active Surveillance for Prostate Cancer: An Overview
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Laurence Klotz
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8 Treatment of Low-Risk, Localized Prostate Cancer: A Holistic Approach With Diet
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Jillian Scambia
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Annie DarvesñBornoz
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Aaron Katz
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9.1 Traditional Radical Prostatectomy
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Zachary L. Smith
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Thomas J. Guzzo
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9.2 Laparoscopic Radical Prostatectomy: Techniques and Complications
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Fernando Pablo Secin
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Karim Touijer
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9.3 Robotic Radical Prostatectomy: The Thomas Jefferson University Experience
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Costas D. Lallas
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Edouard J. Trabulsi
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9.4 Surgical Training, Digital Capture, Virtual Reality, and the Future of Radical Prostatectomy
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Costas D. Lallas
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10.1.1 External Beam Radiation Therapy: Conventional Fractionation
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David E. Greene
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Richard K. Valicenti
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10.1.2 Hypofractionated Radiation Therapy for Localized Prostate Cancer
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Nicholas G. Zaorsky
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Robert B. Den
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10.1.3 Stereotactic Body Radiation Therapy for Localized Prostate Cancer
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Nicholas G. Zaorsky
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Robert B. Den
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10.1.4 Treatment of Low-Risk, Localized Prostate Cancer: Use of Proton Therapy
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Phillip J. Gray
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Ayal A. Aizer
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Jason A. Efstathiou
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10.2 Treatment of Low-Risk, Localized Prostate Cancer: Brachytherapy
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Peter Grimm
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11.1 Treatment of Low-Risk, Localized Prostate Cancer: General Principles of Ablative and Focal Therapies
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Joshua A. Cohn
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Aytekin Oto
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Scott E. Eggener
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11.2 Hyperthermia for Prostate Cancer
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Mark Hurwitz
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11.3 Ablative Techniques: Vascular Targeted Photodynamic Therapy
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Ashley G. Winter
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Jonathan A. Coleman
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11.4 Laser Ablative Techniques for Prostate Cancer
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Ashley G. Winter
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Jonathan A. Coleman
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11.5 Irreversible Electroporation (IRE) Prostate Ablation
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Ashley G. Winter
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Jonathan A. Coleman
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12.1 Quality of Life With Surgery
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Alana M. Murphy
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Patrick J. Shenot
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12.2 Quality of Life With Androgen Deprivation Therapy
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Alana M. Murphy
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Patrick J. Shenot
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12.3 Quality of Life With External Beam Radiation Therapy
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Steve K. Williams
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Sameer Chopra
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Farhang Rabbani
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12.4 Quality of Life With Brachytherapy for Low-Risk Localized Prostate Cancer
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Steve K. Williams
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Farhang Rabbani
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13 Role for Comparative Effectiveness Research in Treatment Decision Making
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Ryan T. Jones
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Mark V. Mishra
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Timothy N. Showalter
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14 Defining Treatment Failure for Localized Prostate Cancer: PSA and Beyond
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Nicholas G. Zaorsky
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Robert B. Den
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Jianqing Lin
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15 Prognosis After Biochemical Failure and Surrogate Endpoints for Prostate CancerñSpecific Mortality
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Peter Orio
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Nathan Bittner
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III.
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Treatment for High-Risk, Localized, and Locally Advanced Disease
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16 Treatment of High-Risk Prostate Cancer: The Role of Low-Dose Rate (LDR) and High-Dose Rate (HDR) Brachytherapy
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Thomas J. Pugh
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IV.
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Treatment of Disseminated Disease
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17 Salvage Therapy for Rising PSA
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Judd W. Moul
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18 Metastatic Hormone Sensitive Prostate Cancer
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Jean Hoffman-Censits
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William Kevin Kelly
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19.1 Metastatic Castrate-Resistant Prostate Cancer: Mechanisms of Hormone Escape
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Susan F. Slovin
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19.2 Metastatic Castrate-Resistant Prostate Cancer: Role of Chemotherapy and Multifaceted Treatment Paradigms
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Abdel Hai Alqwasmi
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Nicholas G. Zaorsky
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Ulka Vaishampayan
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19.3 Metastatic Castrate-Resistant Prostate Cancer: Role of Androgen Signaling Inhibitors
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Austin Poole
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Ajjai Alva
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Julia Batten
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Neeraj Agarwal
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19.4.1 Radiation and the Immune System
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Andrew Sharabi
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Charles Drake
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19.4.2 Immunotherapy: Agents Targeting Prostate Cancer
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Gurveen Kaur
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Naveed H. Akhtar
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Beerinder K. Singh
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Scott T. Tagawa
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19.5 Treatment of Bony Metastases: Inhibitors of Bone Resorption
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Clara Hwang
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Elisabeth I. Heath
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19.6 Treatment of Bone Metastases: Radiopharmaceuticals
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Hossein Jadvar
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Leslie Ballas
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David I. Quinn
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19.7 Prognostication of Metastatic Castration-Resistant Prostate Cancer
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Alan D. Smith
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Joaquin Mateo
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Johann S. de Bono
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Index
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