Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
Rezensionen / Stimmen
"Dere...introduces types of gap junctions, their structural aspects, expression patterns of connexins (transmembrane proteins), and gap junction- related diseases due to mutations in connexin genes. International researchers working in this emerging field discuss specific connexin genes and their mechanisms of action and function in the developing neocortx, behavior, and neurological and neuropsychiatric diseases." --Reference and Research Book News, February 2013
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science Publishing Co Inc
Zielgruppe
Für Beruf und Forschung
Researchers in neuroscience, neuropsychology, psychiatry and biology
Produkt-Hinweis
Fadenheftung
Gewebe-Einband
Maße
Höhe: 285 mm
Breite: 225 mm
Dicke: 22 mm
Gewicht
ISBN-13
978-0-12-415901-3 (9780124159013)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Ekrem Dere is full professor for the Pathophysiology of Cerebral Aging at the Pierre et Marie Curie University in Paris, France. His former team at the University in Duesseldorf, Germany, has provided the first behavioral evidence demonstrating that gap junctions in the brain play an important role in various behavioral processes.
Herausgeber*in
Physiological Psychology, University of Duesseldorf, Germany
Section I: Physiology of gap junctions in the brain
Section II: Gap junctions between astrocytes, neurons, and glia-neuron interactions
Section III: The role of gap junctions in brain development, neurogenesis and synaptic plasticity
Section IV: Gap junctions and neuronal synchronization
Section V: Gap junctions and neurological and neuropsychiatric diseases
Section VI: Gap junctions and behavior
