Neurobiology of Alzheimer's Disease

This new edition of a book first published in 1995, presents an accessible and up-to-date overview of Alzheimer's disease, with an emphasis on research into the molecular mechanisms of neuronal degeneration. Leading international experts have provided in-depth reviews of their areas of expertise, including coverage of the key molecules known to be involved, such as APP, tau, apolipoprotein E and the presenilins. Other areas covered include neuropathology, genetics, neurochemical pathology, inflammation, diagnosis, models of the disease and opportunities for treatment, employing both current and emerging drug therapies. The book will provide a readable introduction for those new to the subject, as well as covering a wide range of specialist topics for the more experienced researcher and those interested in the overlap with other related specialist areas. Also included are appendices detailing gene and protein information on APP, tau, the presenilins, apolipoprotein E and the newly cloned therapeutic target, BACE.