"Protein and Pharmaceutical Engineering" brings together a distinguished group of experts who scrutinize the architecture and activity of proteins to uncover the underlying principles of macromolecular form and function. Drawing on this knowledge, the contributors to this volume focus on designing and engineering proteins for the development of pharmaceuticals. The authors employ novel approaches in molecular genetics, enzymology, molecular modelling, NMR spectroscopy and X-ray crystallography to reveal the role primary amino acid sequence plays in protein structure and function. Chapters cover areas of research in two broad categories: physical analysis of protein structure and molecular biochemical aspects of protein function.
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978-0-471-56771-4 (9780471567714)
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PHYSICAL ANALYSIS OF PROTEIN STRUCTURE: Assignment of Histidine Resonances in the NMR Spectrum of Staphylococcal Nuclease Using Site-Directed Mutagenesis; Detection of Conformational Changes in Active Site Mutants of Staphylococcal Nuclease; The Acetylcholine Receptor; CHEMICAL ASPECTS OF PROTEIN FUNCTION: HIV1 Protease: Bacterial Expression, Purification and Characterization; Stereospecific Catalysis by an Antibody; Enzyme Mimics; Manipulative Mutagenesis of Enzymes.
