This study draws on recent advances in molecular, cellular and organismal biology to provide a detailed analysis of the phylogeny and ontogeny of the immune system. It provides descriptions of cellular and molecular interactions in the development of immune function. Although most of this work is based on studies in vertebrates, the observations of cytokine-like molecules in invertebrates are discussed. In a final section, the contributors deal with abnormalities in the development and regulation of the immune system, including primary immunodeficiency diseases, and with the normal ageing of the immune system. Throughout the book, an effort has been made to compare and integrate information from studies in diverse systems, and to discuss the limitations of such comparisons.
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
Maße
Höhe: 234 mm
Breite: 156 mm
Gewicht
ISBN-13
978-0-19-504353-2 (9780195043532)
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Schweitzer Klassifikation
PART I: INTRODUCTION; 1. Basic Concepts and the Functional Organization of the Immune System; PART II: PHYLOGENY OF THE IMMUNE SYSTEM; 2. Development of Primitive Recognition Systems in Invertebrates; 3. Molecular Genetics of the Major Histocompatibility Complex; 4. Evolution of the Immunoglobulin Gene Superfamily; 5. Early Development of Immunoglobulins; 6. The Organization and Assembly of Immunoglobulin Genes; 7. Developmental Control of T Cell Antigen Receptor Gene Rearrangement and Expression; PART III: ONTOGENY OF THE IMMUNE SYSTEM; 8. Stem Cells; 9. Monocytes; 10. T Lymphocytes; 11. B Lymphocyte Generation as a Developmental Process; PART IV: MOLECULAR ASPECTS OF RECOGNITION AND REGULATION; 12. Antigen Processing and Presentation: Functional and Molecular Aspects; 13. Ontogeny and Function of Complement; 14. The Origin and Function of Cytokines Involved in the Development of Immune Responses; 15. T Cell Activation: Functional and Molecular Aspects; 16. Regulation of the B Cell Response: Activation and Differentiation; PART V: DEVELOPMENT OF THE IMMUNE SYSTEM IN HEALTH AND DISEASE; 17. The Thymosins: Immunological Manipulations and Pharmacology; 18. Immune Surveillance and Natural Immunity; 19. The Immunobiology of Aging; 20. Development of Normal and Abnormal Immune Function in Humans
