The simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Comprehensive protocols are provided for the use of alpha toxin, apamin, batrachotoxin, botulina toxin, bungarotoxin, channel ligands: agonists and antagonists, capsaicin, charybdotoxin, ciguatoxin, "clostridium botulinum" neurotoxin, cholera toxin (choleragen), conotoxin, dendrotoxin, endothelin, fasciculin, geographutoxin, latrotoxin, natural toxins, neosurugatoxin, palytoxin, pertussis toxin, resinferatoxin, sarafotoxin, scorpoin toxin, snake venom toxins.
The simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Comprehensive protocols are provided for the use of alpha toxin, apamin, batrachotoxin, botulina toxin, bungarotoxin, channel ligands: agonists and antagonists, capsaicin, charybdotoxin, ciguatoxin, "clostridium botulinum" neurotoxin, cholera toxin (choleragen), conotoxin, dendrotoxin, endothelin, fasciculin, geographutoxin, latrotoxin, natural toxins, neosurugatoxin, palytoxin, pertussis toxin, resinferatoxin, sarafotoxin, scorpoin toxin, snake venom toxins.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science Publishing Co Inc
Zielgruppe
Illustrationen
Maße
Gewicht
ISBN-13
978-0-12-185265-8 (9780121852658)
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Schweitzer Klassifikation
Comparison of alpha toxin and aerolysin for formation of ion-permeable channels, R. Benz and T. Chakraborty; apamin - a probe for low conductance, calcium-activated potassium channels, P.N. Strong and B.S. Brewster; batrachotoxin a [3H]benzoate binding to sodium channels, C.R. Creveling and J.W. Daly; botulinal neurotoxins - mode of action on neurotransmitter release, B. Poulain and J. Molgo; botulinum toxin as a tool in neurobiology, L.L. Simpson; alpha-bungarotoxin receptor from chick optic lobe - biochemical, immunological and pharmacological characterization, C. Gotti et al; channel ligands used to probe role of voltage-sensitive calcium-ion channels in neuropeptide release, M. Treiman et al; modulation of acetylcholine release by calcium channel antagonists, I. Wessler; capsaicin - a probe for studying neuronal populations in brain and retina, S. Ritter and T.T. Dinh; charybdotoxin in study of voltage-dependent potassium channels, M.L. Garcia et al; ciguatoxin - a tool for research on sodium-dependent mechanisms, J. Molgo et al; purification and radiolabeling of clostridium botulinium type f neurotoxin, C.H. Shone et al; retrograde tracing with cholera toxin b-gold or with immunocytochemically detected cholera toxin b in central nervous system, I.J. Llewellyn-Smith et al; omega-conotoxin - calcium currents and neurosecretion, K. Takeda and J.J. Nordmann; omega-conotoxin GVIA and its receptors, M. Takemura; dendrotoxin acceptor sites - identification and labeling of brain potassium channels, M.P. Blaustein and R.G. Sorensen; endothelins and sarafotoxin in neural tissues, C. Frelin and J.-P. Breittmayer; fasciculin - neuropharmacology of potent anticholinesterase polypeptide, F. Dajas et al; geographutoxins, H. Nakamura et al; presynaptic activity of alpha-latrotoxin - purification and properties, Y.A.T. Terletskaya et al; natural toxins in study of degeneration and regeneration of skeletal muscle, J.B. Harris; neosurugatoxin - a probe for neuronal nicotinic receptors in adrenal medulla, brain, and ganglia, A. Wada et al; neurotoxins as tools in characterization of gamma-aminobutyric acid-activates chloride channels, F. Zufall; palytoxin - characterization of mode of action in excitable cells, M.-P. Sauviat; palytoxin - mechanism of acidifying action in excitable cells, C. Frelin and J.-P. Breittmayer; pertussis toxin in analysis of receptor mechanisms, T. Reisine and S.F. Law; resiniferatoxin, A. Szallasi and P.M. Blumberg; scorpion toxins affecting insects, E.P. Loret et al; potassium channel-blocking toxins from snake venoms and neuromuscular transmission, A.L. Harvey et al.
