This comprehensive volume updates coverage on the NMDA receptor - an important protein in the brain involved in the electrical and chemical processes which may underlie learning and memory. These receptors are also thought to contribute to, for example, stroke-induced brain damage and Alzheimer's disease, and so there is considerable interest in drug development based on the NMDA receptor. Each chapter includes the most recent developments, and is written by leading experts in the field. The book should be of interest to neuroscientists, pharmacologists and physiologists all the way through from senior undergraduate to principal investigators.
Auflage
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Editions-Typ
Illustrationen
1 colour illustration, halftones, numerous line figures, tables, bibliography
ISBN-13
978-0-19-262371-3 (9780192623713)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Herausgeber*in
Professor and Head of Department, Department of PharmacologyProfessor and Head of Department, Department of Pharmacology, University of Birmingham
Professor of PharmacologyProfessor of Pharmacology, University of Bristol
Agonists and competitive antagonists - structure, activity and molecular modelling studies; non-competitive antagonists of N-methyl-D-aspartate; molecular pharmacology of NMDA receptors; molecular biology of NMDA receptors; anatomical, pharmacological and molecular diversity of native NMDA receptor subtypes; the NMDA receptor, its channel and its modulation by glycine; the time-course of NMDA receptor-mediated synaptic currents; activation of NMDA receptors; NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system; the importance of NMDA receptors in the processing of spinal primary afferent input patterns; the role of NMDA receptors in synaptic integration and the organization of motor patterns; NMDA receptors and long-term potentiation in the hippocampus; NMDA receptors and developmental plasticity in visual neocortex; the role of NMDA receptors in learning and memory; clinical implications of NMDA receptors; the NMDA receptor in epilepsy; NMDA receptors, neuronal development and neurodegeneration; competitive NMDA antagonists as drugs; non-competitive NMDA antagonists as drugs; the NMDA receptor concept - origins and development.
