List of contributors. Preface. Section I. Introductory Overview. Neural plasticity in aging and Alzheimer's disease: Some selected comments (C.H. Phelps). Section II. Cell Death . Glucocorticoids, hippocampal damage and the glutamatergic synapse (R.M. Saplosky). Hormones and programmed cell death: Insights from invertebrate studies (J.W. Truman, S.E. Fahrbach and K. Kimura). Excitotoxin-mediated neuron death in young and old age (J.W. Olney). Section III. Plasticity in Normal and Aging Systems and in AD . Plasticity of excitatory amino acid receptors: Implications for aging and Alzheimer's disease (C.W. Cotman, J.W. Geddes, J. Ulas and T. Klein). Neurono-glial interactions and neural plasticity (G. Moonen, B. Rogister, P. Leprince, J.-P. Rigo, P. Delree, P.P. Lefebvre and J. Schoenen). Neuronal plasticity in normal aging and deficient plasticity in Alzheimer's disease: A proposed intercellular signal cascade (P.D. Coleman, K.E. Rogers and D.G. Flood). Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus (C.A. Barnes). Synaptic plasticity and behavioral modifications in the marine mollusk Aplysia (V.F. Castellucci and S. Schacher). Integration by the neuronal growth cone: A continuum from neuroplasticity to neuropathology (S.B. Kater, P.B. Guthrie and L.R. Mills). Intracortical processes regulating the integration of sensory information (F.F. Ebner and M.A. Armstrong-James). Section IV. Intercellular Mechanisms: Growth Factors and Their Receptors. Selective and non-selective trophic actions on central cholinergic and dopaminergic neurons in vitro (F. Hefti, B. Knusel and P.P. Michel). Neurotrophic factors in the CNS: Biosynthetic processing and functional responses (R.A. Bradshaw, J.G. Altin, M. Blaber, K.P. Cavanaugh, D.D. Eveleth, H.I. Kornblum, F.M. Leslie and S. Raffioni). S100-beta as a neurotrophic factor (D.R. Marshak). Growth factor-mediated protection in aging CNS (K. Werrbach-Perez, G. Jackson, D. Marchetti, B. Morgan, L. Thorpe and J.R. Perez-Polo). The brain nicotinic acetylcholine receptor gene family (S. Heinemann, J. Boulter, E. Deneris, J. Connolly, R. Duvoisin, R. Papke and J. Patrick). Gene therapy in the CNS: Intracerebral grafting of genetically modified cells (F.H. Gage, M.B. Rosenberg, M.H. Tuszynski, K. Yoshida, D.M. Armstrong, R.C. Hayes and T. Friedmann). Section V. Intracellar Molecular Mechanisms . Receptors, phosphoinositol hydrolysis and plasticity of nerve cells (N.J. Pontzer, L.J. Chandler, B.R. Stevens and F.T. Crews). Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing central nervous system (M.P. McKinley, F.M. Longo, J.S. Valletta, F. Rahbar, R. Neve, S.B. Prusiner and W.C. Mobley). Trophic regulation of basal forebrain gene expression in aging and Alzheimer's disease (G.A. Higgins, S. Koh, R.L. Neve, E.J. Mufson, K.S. Chen and F.H. Gage).
