Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.
Rezensionen / Stimmen
"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology
"This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology
Auflage
Softcover reprint of the original 1st ed. 2002
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Professional/practitioner
Illustrationen
Maße
Höhe: 297 mm
Breite: 210 mm
Dicke: 33 mm
Gewicht
ISBN-13
978-1-61737-107-3 (9781617371073)
DOI
10.1007/978-1-59259-125-1
Schweitzer Klassifikation
I. Introduction.- 1 Cancer Epidemiology: Incidence and Etiology of Human Neoplasms.- II. Essential Concepts in Molecular Biology.- 2 Essential Concepts and Techniques in Molecular Biology.- III. Molecular Themes in Oncogenesis.- 3 Cancer Genes.- 4 Positive Mediators of Cell Proliferation in Neoplastic Transformation.- 5 Inactivation of Negative Growth Regulators During Neoplastic Transformation.- IV. Mechanisms of Mutation.- 6 The Role of Genomic Instability in the Development of Human Cancer.- 7 Chromosomes and Chromosomal Instability in Human Cancer.- 8 Hereditary Cancer.- V. Etiology of Human Cancers.- 9 Evolution of Research in Cancer Etiology.- 10 Cellular Responses to Chemical Carcinogens.- 11 Physical Agents in Human Carcinogenesis.- 12 Viral Mechanisms of Human Carcinogenesis.- VI. Human Tumor Systems.- 13 The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway.- 14 Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma.- 15 The Molecular Basis of Breast Carcinogenesis.- 16 The Molecular Basis of Prostate Carcinogenesis.- 17 The Molecular Basis of Lung Carcinogenesis.- 18 The Molecular Basis of Skin Carcinogenesis.- 19 The Molecular Biology of Leukemias.- 20 Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma.- VII. Future Directions.- 21 Cancer Genetic Counseling.- 22 Molecular Genetic Diagnosis of Inherited Cancer Predisposition.- 23 Novel Molecular Targets for Cancer Drug Discovery.- 24 Gene Therapy in the Treatment of Human Cancer.
