Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.
Rezensionen / Stimmen
"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies...The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced...the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology "This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology
Auflage
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Professional/practitioner
Illustrationen
Maße
Höhe: 29.7 cm
Breite: 21 cm
Gewicht
ISBN-13
978-0-89603-634-5 (9780896036345)
DOI
10.1007/978-1-59259-125-1
Schweitzer Klassifikation
Part I. Introduction
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
William B. Coleman and Gregory J. Tsongalis
Part II. Essential Concepts in Molecular Biology
Essential Concepts and Techniques in Molecular Biology
Sharon Collins Presnell
Part III. Molecular Themes in Oncogenesis
Cancer Genes
John J. Reinartz
Positive Mediators of Cell Proliferation in Neoplastic Transformation
James N. Welch and Susan A. Chrysogelos
Inactivation of Negative Growth Regulators During Neoplastic Transformation
Kara N. Smolinski and Stephen J. Meltzer
Part IV. Mechanisms of Mutation
The Role of Genomic Instability in the Development of Human Cancer
William B. Coleman and Gregory J. Tsongalis
Chromosomes and Chromosomal Instability in Human Cancer
Takashi Shimamoto and Kazuma Ohyashiki
Hereditary Cancer
Bruce M. Boman, Lael Melchert, and Jeremy Z. Fields
Part V. Etiology of Human Cancers
Evolution of Research in Cancer Etiology
Lorenzo Tomatis and James Huff
Cellular Responses to Chemical Carcinogens
Edward L. Loechler, Bryan Henry, and Kwang-Young Seo
Physical Agents in Human Carcinogenesis
Cynthia R. Timblin, Yvonne Janssen-Heininger, and Brooke T. Mossman
Viral Mechanisms of Human Carcinogenesis
Felix Hoppe-Seyler and Karin Butz
Part VI. Human Tumor Systems
The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway
J. Milburn Jessup, Gary Gallick, and Bo Liu
Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma
Joe W. Grisham
The Molecular Basis of Breast Carcinogenesis
April Charpentier and C. Marcelo Aldaz
The Molecular Basis of Prostate Carcinogenesis
Allen C. Gao and John T. Isaacs
The Molecular Basis of Lung Carcinogenesis
Kwun M. Fong, Yoshitaka Sekido, and John D. Minna
The Molecular Basis of Skin Carcinogenesis
Caterina Missero, Mariarosaria D'Errico, Gian Paolo Dotto, and Eugenia Dogliotti
The Molecular Biology of Leukemias
Arnold B. Gelb and L. Jeffrey Medeiros
Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma
Gregory J. Tsongalis and William N. Rezuke
Part VII. Future Directions
Cancer Genetic Counseling
Katherine Schneider, Kristen Shannon, Anu Chittenden, Elaine Hiller, and Stephanie Kieffer
Molecular Genetic Diagnosis of Inherited Cancer Predisposition
Elizabeth M. Petty and Beverly M. Yashar
Novel Molecular Targets for Cancer Drug Discovery
John K. Buolamwini
Gene Therapy in the Treatment of Human Cancer
Jesús Gómez-Navarro, Guadalupe Bilbao, and David T. Curiel
