This is a high-level reference work on the preclinical and clinical aspects of recombinant human follicle-stimulating hormone (recFSH), Puregon. It contains the complete text, with illustrations, of 13 previously published key articles on FSH by leading specialists in obstetrics and gynecology, reproductive medicine, reproductive endocrinology and infertility, physiology, and pharmacology. These papers are the foundation for experimental studies on recFSH and for its clinical use with problems of infertility in gonadotropin-deficient women, in cases of polycystic ovary syndrome, for induction of spermatogenesis in hypogonadotropic males, and for in vitro fertilization.
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978-1-85070-746-2 (9781850707462)
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Schweitzer Klassifikation
Preclinical Aspects-Comparative in vitro and in vivo studies on the biological characteristics of recFSHoEffects of recFSH on cultured human granulosa cellso Circulating bioactive and immunoreactive recFSH after administration to gonadotropin-deficient subjectsoFolliculogenesis in hypophysectomized rats after treatment with recFSHoRecFSH induces follicle growth and ovulation in the adult cyclic rat. Clinical Aspects-First established pregnancy and birth after ovarian stimulation with recFSHoRecFSH induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiencyoSingle-dose pharmacokinetics and pharmacodynamics of recFSH in gonadotropin-deficient volunteersoClinical outcome of pilot efficacy study on recFSH combined with various gonadotropin-releasing hormone agonist regimensoRecFSH and ovarian response in gonadotropin-deficient womenoFirst established pregnancy and birth after induction o f ovulation with recFSH in polycystic ovary syndromeoRecFSH an human chorionic gonadotropin for induction of spermatogenesis in hypogonadotropic malesoA prospective, randomized, assessor-blind, multicenter study comparing recombinant and urinary FSH in in vitro fertilization. Index.
