The Second Edition of this comprehensive reference combines a strong scientific base with a clinical focus to address the principal disorders of bone and mineral metabolism, including osteoporosis, kidney stone formation, abnormal serum mineral levels, Paget's disease, and other conditions. The contributors examine normal bone structure and mineral metabolism throughout the life cycle, explain the mechanisms underlying each disorder, and provide succinct guidance on evaluation and management. This edition describes recently introduced drugs, thoroughly reviews powerful new treatments for osteoporosis and nephrolithiasis and also features completely rewritten chapters on stone formation. Over than 500 illustrations complement the text plus over 150 tables help readers find needed information at a glance
The Second Edition of this comprehensive reference combines a strong scientific base with a clinical focus to address the principal disorders of bone and mineral metabolism, including osteoporosis, kidney stone formation, abnormal serum mineral levels, Paget's disease, and other conditions. The contributors examine normal bone structure and mineral metabolism throughout the life cycle, explain the mechanisms underlying each disorder, and provide succinct guidance on evaluation and management. This edition describes recently introduced drugs, thoroughly reviews powerful new treatments for osteoporosis and nephrolithiasis and also features completely rewritten chapters on stone formation. Over than 500 illustrations complement the text plus over 150 tables help readers find needed information at a glance
Auflage
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Editions-Typ
Illustrationen
Maße
Höhe: 279 mm
Breite: 216 mm
Gewicht
ISBN-13
978-0-7817-1789-2 (9780781717892)
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Schweitzer Klassifikation
Contributing Authors Preface I. NORMAL MINERAL METABOLISM 1. Renal Handling of Calcium and Phosphorous 2. Physiology and Pathophysiology of Renal Magnesium Handling 3. Intestinal Absorption of Calcium, Magnesium, and Phosphorus 4. Parathyroid Hormone - Synthesis and Secretion 5. Target Tissue Actions, Metabolism, and Assay of Parathyroid Hormone 6. Parathyroid Hormone-Related Protein 7. Vitamin D: Synthesis, Metabolism, and Clinical Measurement II. BONE STRUCTURE AND BIOLOGY 8. Embroyology, Anatomy, and Microstructure of Bone 9. The Cell and Molecular Biology of Bone Formation 10. Mechanisms of Biomineralization 11. Mechanisms and Regulation of Bone Resorption by Osteoclastic Cells 12. The Biology, Chemistry, and Biochemistry of the Mammalian Growth Plate 13. Bone Remodeling III. MINERAL METABOLISM DURING THE HUMAN LIFE CYCLE 14. Mineral Metabolism During Pregnancy and Lactation 15. Bone and Mineral Metabolism During Childhood 16. Integration of Calcium Metabolism in the Adult IV. INTRODUCTION TO CLINICAL MINERAL DISORDERS 17. Clinical and Laboratory Approach to the Patient with Disorders of Bone and Mineral Metabolism 18. Bone Mass Measurement 19. Radiological Imaging of Metabolic Bone Disease 20. Clinical Use of Bone Biopsy 21. The Physiologic and Pathogenetic Significance of Bone Histomorphometric Data V. DISORDERS OF SERUM MINERAL LEVELS 22. Hypercalcemic States: Differential Diagnosis and Acute Management 23. Primary Hyperparathyroidism 24. Disorders of Serum Minerals Caused by Cancer 25. Hypercalcemia and Abnormal Vitamin D Metabolism 26. The Hypercalcemic States 27. Disorders of Phosphate and Magnesium Metabolism VI. DISORDERS OF STONE FORMATION 28. Physical-Chemical Processes in Kidney Stone Formation 29. Mechanisms of Stone Disruption and Dissolution 30. Idiopathic Hypercalciuria 31. Hyperoxaluric States 32. Calcium Nephrolithiasis and Renal Tubular Acidosis 33. Inhibitors and Promoters of Calcium Oxalate Crystallization: Their Relationship to the Pathogenesis and Treatment of Nephrolithiasis 34. Noncalcium Urinary Calculi VII. DISODERS OF BONE 35. Primary Osteoporosis 36. Treatment of Osteoporosis 37. Secondary Forms of Osteoporosis 38. Bone Disease in Chronic Renal Failure and After Renal Transplantation 39. Bone Disease Resulting from Inherited Disorders of Renal Tubule Transport and Vitamin D Metabolism 40. Bone Disease Due to Nutritional, Gastrointestinal and Hepatic Disorders 41. Hereditary Metabolic and Dysplastic Skeletal Disorders 42. Paget's Disease of Bone 43. Primary Cystic and Neoplastic Diseases of Bone Subject Index
