The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advance has been made on our understanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in details the DNA and
protein components of this structure, and their individual functions, in species as diverse as budding and fission yeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling "passenger" proteins; important emerging concepts such as latest centromeres and
epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application of centromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject
Rezensionen / Stimmen
'This book is an excellent review of recent advances in the understanding of both the structure and function of the centromer. It is clearly written with good illustrations throughout...This is a well-written and researched book about the centromere which should be in the library of any university or laboratory involved with research or teaching of cytogenetics. * Anne Kaukas, SGM Quarterly, Nov.1998 *
Sprache
Verlagsort
Zielgruppe
Illustrationen
Maße
Höhe: 235 mm
Breite: 157 mm
Dicke: 17 mm
Gewicht
ISBN-13
978-0-19-857780-5 (9780198577805)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Autor*in
DoctorThe Murdoch Institute for Research into Birth Defects, Melbourne
1. Introduction ; 2. Centromere of budding yeast S. cerevisiae ; 3. Centromere of fission yeast S. pombe ; 4. Structural Organization and general properties of the higher eukaryotic centromere ; 5. Centromere DNA of higher eukaryotes ; 6. Centromere proteins of higher eukaryotes ; 7. Anomalies of the human centromere ; 8. Practical applications
