This book deals with new therapies that use cells such as stem cells to treat, retard, or even cure devastating muscle diseases such as Parkinson's, Lou Gehrig's disease (ALS), and muscular dystrophy. The text is divided into two parts. The first part contains chapters by contributors establishing basic aspects of cellular therapies, focusing mostly on muscle disorders. The second part deals with specific disorders, especially Duchenne Muscular Dystrophy. Together, these two parts provide insight into the rapidly changing field of available cellular therapies.
Key selling features:
Provides a foundation for the use of cell therapies in the treatment of muscle disorders
Deals with specific disorders, especially Duchene Muscular Dystrophy
Includes the contributions of leading researchers who are actively exploring cell therapeutic methods
Reihe
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
This book is intended for stem cell researchers, clinical researchers and medical doctors researching the causes and cures for a wide variety of muscle disorders. It also would be useful to researchers studying neuromuscular junctions and neuromuscular physiology and post-doctoral researchers studying muscle biology and muscle disease.
Illustrationen
36 s/w Abbildungen
36 Illustrations, black and white
Maße
Höhe: 234 mm
Breite: 156 mm
ISBN-13
978-1-4822-2788-8 (9781482227888)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Martin Childers, D.O., Ph.D, is a professor of rehabilitation medicine at the University of Washington, Seattle, USA.
Herausgeber*in
University of Washington, Seattle, USA
Foundations for cell therapy in muscle disorders. GMP considerations for clinical cell products. Commercialization and investment issues. Regulatory issues for cell therapy. Immunologic considerations for cell transplantation. Developmental biology and muscle cell transplantation. Identification and Characterization of Satellite Stem Cells. Hemangioblasts in skeletal muscle disorders. Derivation of muscle cells from iPS. Primary muscles cells and transplantation. Use of physical modalities in muscle cell transplantation. Use of viral vectors for ex vivo correction of muscle cells. Role of animal models in cell therapy for muscle disorders. Specific Disorders. Genetic correction of MPCS derived from iPS cells for LGMD. Myoblast transplantation in DMD. Genetic correction of human iPS for transplantation in spinal muscular atrophy. Local injection of stem cells in the diaphragm for DMD. In utero and Neonatal Stem Cell Therapy for Duchenne Muscular Dystrophy. Mechanically Programmed Adipose-Derived Stem Cells to Treat Muscular Dystrophy.
