Biomarkers play an indispensable role in Alzheimer's Disease (AD) diagnosis, clinical research and clinical trials. Our understanding of AD biomarkers has been profoundly impacted by the study of Autosomal Dominant Alzheimer's Disease (ADAD). Though memory loss is the most common feature of ADAD, motor dysfunction, neuropsychiatric symptoms, and epileptiform abnormalities are present at a much higher rate in ADAD than sporadic, late-onset AD. There are over 250 known ADAD-causative variants in PSEN1, 2, and APP. This genetic heterogeneity is reflective in both biomarkers and cognitive heterogeneity across people with ADAD. Autosomal Dominant Alzheimer's Disease: A Pathophysiology Review discusses the history of ADAD and its cognitive, neuroimaging and biomarker trajectories. This book focuses how ADAD can provide a unique insight into genetically driven and sporadic forms of AD. Edited by Dr. Jasmeer Chhatwal and Dr. Eric McDade, and contributed by leading experts in the field, this book will be become the leading tool for researchers and clinicians in Alzheimer's Disease.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Maße
Höhe: 229 mm
Breite: 151 mm
ISBN-13
978-0-323-99716-4 (9780323997164)
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Schweitzer Klassifikation
Jasmeer Chhatwal MD PhD MMSc, Assistant Professor of Neurology, Harvard Medical School; Associate Neurologist, Massachusetts General Hospital. Dr. Chhatwal is a neurologist and translational neuroscientist at Harvard Medical School who uses a diverse array of genetic, neuroimaging, and biochemical tools to study Alzheimer's disease. He serves as a site leader for the Dominantly Inherited Alzheimer's Network (DIAN), a project leader for the Harvard Aging Brain Study, and leads studies examining potentially modifiable risk factors for cognitive decline in older adults. Clinically, he sees a wide variety of patients with cognitive disorders, with a particular focus on early onset Alzheimer's disease (AD). Eric McDade, DO, Associate Professor of Neurology, Washington University School of Medicine at St. Louis. Dr. McDade is a Neurologist with a specialty in Cognitive Neurology. He is the Associate Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and the Clinical Core lead of the Dominantly Inherited Alzheimer Network. Dr. McDade's clinical research focuses on fluid and imaging biomarkers in preclinical Alzheimer disease and their application in the development of Alzheimer prevention clinical trials. He leads the DIAN-TU Primary Prevention Trial.
Herausgeber*in
Massachusetts General Hospital / Martinos Center for Biomedical Imaging, USA
Washington University School of Medicine, USA
1. Introduction 2. History of ADAD 3. Cognitive Trajectories in ADAD 4. Beyond Memory Loss: Non-Amnestic Manifestations of ADAD 5. Towards a Unified Framework in Sporadic and Genetically driven AD: Neuroimaging and Biomarker Trajectories in ADAD 6. Applying lessons from ADAD to sporadic AD 7. Mechanisms underlying ADAD mutations 8. Heterogeneity Across ADAD Genotypes 9. Lessons from AD in Down's Syndrome 10. Neuropathology of ADAD 11. ADAD Experimental Therapeutics
