Part I General Sections
Section I: Basic Principles
1 Principles of Clinical Molecular Biology
Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, and Liang Cheng, MD
2 Principles of Clinical Cytogenetics
Stuart Schwartz, PhD, FACMG
3 Conceptual Evolution in Cancer Biology
Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Gregory T. MacLennan, and Liang Cheng, MD
4 Genetic Inheritance and Population Genetics
Tatiana Foroud, PhD, and Daniel L. Koller, PhD
5 Clonality Analysis and Tumor of Unknown Primary: Applications in Modern Oncology and Surgical Pathology
Liang Cheng, MD, Shaobo Zhang, MD, Federico A. Monzon, MD, Timothy D. Jones, MD
6 Modern Immunohistochemistry in Targeted Therapy
Allen M. Gown
7 Systems Pathology
Jose Costa, MD and Michael Donovan, MD
Section II: Methodology
8 Diagnostic Methodology and Technology
Josephine Wu MD, Fei Ye MD, Miao Cui MD, Robert Shibata MD, Ruliang Xu MD, Liang Cheng MD, David Y. Zhang MD
9 Clinical Flow Cytometry
Magdalena Czader, MD, PhD
10 Clinical Genomics in Oncology
Hugo M. Horlings, MD, PhD Thalia Farazi, MD, PhD and
Marc van de Vijver, MD, PhD
11 Clinical Proteomics
David H. Geho, MD, PhD, Virginia Espina, MS, Lance A. Liotta, MD, PhD, Emanuel F. Petricoin, PhD, and Julia D. Wulfkuhle, PhD
12 Nanotechnology in Molecular Diagnostics
Andrew N Young MD PhD and Brad A Kairdolf PhD
13 Gene Therapy: Vector Technology and Clinical Applications
Sunyong Tang, PhD and Kenneth Cornetta, MD
14 Instrumentation for Molecular Testing
Jordan Laser MD, Miao Cui MD, Bruce E. Petersen MD, Fei Ye MD, David Y. Zhang MD
15 Tissue Microarrays and Biomarker Validation
Martina Storz, BS and Holger Moch, MD
16 Laser Capture Microdissection Liang Cheng MD, Shaobo Zhang MD, Darrell D. Davidson MD, Matthew Kuhar MD, Mingsheng Wang MD, David Y. Zhang MD, Gregory T. MacLennan MD
17 Human Tissue Biorepository
William E. Grizzle, Katherine C. Sexton, Walter C. Bell
18 Pathology Informatics
Roy E Lee MD, Long P Le MD PhD, John R Gilbertson MD
Part II. Clinical Application and Disease-Based Sections
Section III: Genetic Disorders
19 Prenatal Cytogenetic and Cytogenomic Diagnosis
Ninette Cohen, PhD and Lisa Edelmann, PhD
20 Molecular Medical Genetics
Lisa Edelmann, PhD, Stuart A. Scott, PhD, Liu Liu, PhD,
Ruth Kornreich, PhD
21 Biochemical Genetics and Inborn Errors of Metabolism
Chunli Yu, MD, Melissa Wasserstein, MD, George Diaz, MD, PhD
22 Molecular Genetics of Congenital Heart Disease
Abigail E Southard, BA and Bruce D Gelb, MD
23 Familial Cancer Syndromes
Beth Harrison, MD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Michelle P. Elieff, MD, Liang Cheng, MD
24 Genetic Counseling
Kimberly A Quaid, PhD and Lisa J Cushman, PhD
Section IV: Molecular Microbiology
25 Molecular Virology
Fei Ye MD, Miao Cui MD, Rame Khasawneh MD, Robert Shibata MD, Josephine Wu MD, Mona Sharaan MD, David Y. Zhang MD
26 Molecular Bacteriology and Mycobacteriology
Jeong Hwan Shin, MD, PhD, Mona Sharaan, MD, Josephine Wu, DDS, CLSP(MB), CLDIR, Miao Cui, MD, David Y. Zhang, MD, PhD, MPH, Yi-Wei Tang, MD, PhD
27 Molecular Parasitology and Mycology
Vincent J LaBombardi, PhD, Wei Wang, PhD
28 Molecular Microbiology in Transplantation
Adnan A Alatoom, MD and Robin Patel, MD
29 Molecular Microbiology Epidemiology
Miao Cui MD, Fei Ye MD, David Y. Zhang MD
Section V: Hematologic Malignancies
30 Principle of Immunoglobulin and T Cell Receptor Gene Rearrangement
Jeffrey E. Miller, PhD
31 Molecular Diagnostics of Lymphoblastic Leukemia and Lymphoma
Zeqiu J Han, MD and Dan Jones, MD, PhD
32 Molecular Diagnostics of Myeloid Neoplasms
C Cameron Yin, MD, PhD and Dan Jones, MD, PhD
33 Molecular Diagnostics of Lymphoid Malignancies
Vasiliki Leventaki, MD and Francisco Vega, MD, PhD
34 Molecular Diagnostics of Myeloproliferative Neoplasms and Myelodysplastic Syndromes
Gerlinde Wernig, MD, and Daniel A. Arber, MD
35 Molecular Diagnostics of Lymphoproliferative Disorders
Timothy C. Greiner, MD
Section VI: Hematological Disorders and Specialized Applications
36 Molecular Testing for Coagulation Abnormalities
Veshana Ramiah, MD and Thomas L. Ortel, MD, PhD
37 Molecular Hemoglobinopathies
Tina Y. Fodrie, BS, MT, MP (ASCP), Shaobo Zhang, MD, Minaxiben Patel, MT, MP (ASCP), Jodi A. Parks, MD, and Liang Cheng, MD
38 The HLA System and Transfusion Medicine: Molecular Approach
S Yoon Choo, MD
39 Clinical Pharmacogenomics
Catalina Lopez-Correa, MD, PhD and Lawrence M. Gelbert, PhD
40 Molecular Forensic Pathology
Stephen R. Dlouhy, PhD and P. Michael Conneally, PhD
41 Specimen Identification and Bone Marrow Engraftment Analysis
Loren J Joseph, MD
42 Circulating Tumor Cells: The Liquid Biopsy for Molecular Pathology
Jeffrey S. Ross, MD
Section VII: Laboratory Management
43 Ethical and Legal Issues in Molecular Testing
Kimberly A. Quaid, PhD
44 Regulatory Issues in Molecular Testing
Frank S. Ong MD, Wayne W. Grody MD PhD, Kingshuk Das, MD
45 Molecular Pathology Reporting
Stacey S. O'Neill MD PhD and Margaret L. Gulley MD
46 Quality Assurance and Laboratory Inspection
Kristin M. Post, MT(ASCP) and Liang Cheng, MD
