The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect, meanwhile, refers to utilizing the tools and perspectives of epidemiology to comprehend observations in molecular biology. An increasingly sophisticated variety of molecular
techniques are being applied to generate an explosion of data on exposures and outcomes whose significance must be determined.
The wealth of information generated by the Human Genome Project and the corresponding efforts in microbial genomics are providing researchers with extraordinary new opportunities to further understand the etiology of disease. Molecular epidemiology is rapidly evolving through the application of more relevant markers of exposure and better identification of subgroups at increased risk of early disease processes and progression.
This volume provides a broad overview of the diverse approaches encompassed by this emerging discipline. Chapters 1-3 highlight concepts and methods at the forefront of studies of infectious diseases, and include a synopsis of general epidemiologic design and analysis, as well as current techniques for molecular typing of microbial pathogens. Chapters 4-6 are focussed on recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms,
identification of linkage among alleles of genes on a given chromosome, and the use of DNA pooling to increase efficiency in association studies of genetically complex traits. Chapters 7 and 8 deal with the relationship between pathologies and immune system genetics, and on the use of DNA sequence information to
garner insights into the evolution of infectious pathogens, and into the evolution and function of the immune system.
Rezensionen / Stimmen
Each chapter has been written with new researchers in mind, with an easily navigable layout and succinct definitions of specialist terms. The examples provided are presented well and the authors successfully avoid redundant statements, making the information accessible and easy to digest...Molecular Epidemiology was a delight to read and would be invaluable for an undergraduate module. * Journal of Biological Education, 2002, 36 (3) *
Reihe
Sprache
Verlagsort
Zielgruppe
Illustrationen
numerous tables, figures and 5 half tones
Maße
Höhe: 246 mm
Breite: 189 mm
Dicke: 15 mm
Gewicht
ISBN-13
978-0-19-963810-9 (9780199638109)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Herausgeber*in
National Cancer Institute, Frederick, Maryland, USA
Department of Biological Sciences, University of Durham, UK
Introduction ; 1. Epidemiological methods for studies of genetic factors that influence infectious diseases ; 2. Molecular Differentiation of bacterial strains ; 3. Detection and quantification of heterogeneous viral targets: using HIV as a model ; 4. Mutation Detection by Single-Stranded Conformation Polymorphism and Denaturing High Performance Liquid Chromatography ; 5. DNA Pooling Methods for association mapping of complex disease loci ; 6. Single-sperm typing: a rapid alternative to family based linkage analysis ; 7. PCR-based methods of HLA typing ; 8. Evolutionary Analysis of Molecular Sequence Data
