Contributors vii
1. Introduction: Why Should We Care about Organic Chemicals and Human Health? 1
David O. Carpenter
2. Sources of Human Exposure 8
Martí Nadal and José L. Domingo
3. The Burden of Cancer from Organic Chemicals 26
Molly M. Jacobs, Rachel I. Massey, and Richard W. Clapp
4. Carcinogenicity and Mechanisms of Persistent Organic Pollutants 57
Gabriele Ludewig, Larry W. Robertson, and Howard P. Glauert
5. Diabetes and the Metabolic Syndrome 101
Duk-Hee Lee and David R. Jacobs, Jr.
6. Mechanistic Basis for Elevation in Risk of Diabetes Caused by Persistent Organic Pollutants 130
Jérôme Ruzzin
7. Cardiovascular Disease and Hypertension 143
Marian Pavuk and Nina Dutton
8. Obesity 174
Eveline Dirinck, Adrian Covaci, Luc Van Gaal, and Stijn Verhulst
9. Effects and Predicted Consequences of Persistent and Bioactive Organic Pollutants on Thyroid Function 203
Stefanie Giera and R. Thomas Zoeller
10. An Overview of the Effects of Organic Compounds on Women's Reproductive Health and Birth Outcomes 237
Susan R. Reutman and Juliana W. Meadows
11. Effects of Organic Chemicals on the Male Reproductive System 315
Lars Rylander and Anna Rignell-Hydbom
12. Effects of Endocrine-Disrupting Substances on Bone and Joint 332
Chi-Hsien Chen and Yueliang Leon Guo
13. Organic Chemicals and the Immune System 362
David O. Carpenter
14. Exposures to Organic Pollutants and Respiratory Illnesses in Adults and Children 384
Krassi Rumchev, Jeff Spickett, and Janelle Graham
15. Cognitive Function 400
Lizbeth López-Carrillo and Mariano E. Cebrián
16. Intellectual Developmental Disability Syndromes and Organic Chemicals 421
David O. Carpenter
17. Mechanisms of the Neurotoxic Actions of Organic Chemicals 448
David O. Carpenter
18. Parkinson's Disease 471
Samuel M. Goldman
19. Psychiatric Effects of Organic Chemical Exposure 514
James S. Brown, Jr.
20. Growth and Development 532
Lawrence M. Schell, Mia V. Gallo, and Kristopher K. Burnitz
21. How Much Human Disease Is Caused by Exposure to Organic Chemicals? 557
David O. Carpenter
Index 570
