The new experimental tools and approaches of modern biology have allowed us to better understand many fundamental properties of the eukaryotic cells. These significant discoveries have drastically changed the diagnostic and therapeutic approaches of modern clinical practice. On April 18-22, 1988, an International Symposium on Cell Function and Disease was held in Monterrey, Nuevo Leon, Mexico, aimed at reviewing some of the most recent advances made in the following five areas: Genes and Human Diseases; Cellular and Molecular Pathology; Infectious Diseases; Brain Transplants and the New Approaches and Techniques with Potential Application to Cell Function and Disease. This book is based on the contributed papers of the symposium. To underline the importance of the clinical approach to the study of cell function and disease a section on this subject was added at the end of the book. The chapters in this volume include contributions by some of the leading scientists of the international scientific community and Mexico.
During the course of this international conference, numerous discussions were held by the local and international representatives of the scientific community concerning the creation of an International Center of Molecular Medicine aimed at stimulating further interaction between molecular biologists, biochemists, biophyscists and clinicians. Such ideas received the endorsement and support of the Director General of the united Nations Educational and Scientific Organization (UNESCO), Federico Mayor, the Governor of the State of Nuevo Leon, Jorge Trevino, and the Secretary of Health of Mexico, Guillermo Soberon.
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Kluwer Academic Publishers Group
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Für höhere Schule und Studium
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ISBN-13
978-0-306-43201-9 (9780306432019)
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Schweitzer Klassifikation
Genes and Human Diseases.- Towards Active Chromatin Structure.- Molecular Genetics of Wilms' Tumor.- Mecanisms of Altered Growth Regulation in Human Leukemia.- The Human Placental Lactogen and Growth Hormone Multi-Gene Family.- Overproduction of Proteins by Recombinant DNA: Human Insulin.- Diagnosis and Characterization of New Mutations in Man.- Clinical Aspects of Inborn Errors of Metabolism.- Cellular and Molecular Pathology.- Functional Components of Cell Membranes as the Locale of Pathological Phenomena.- Molecular and Physiological Properties of Plasma Membranes: the Role of Ion Channels.- Transmembrane Channels and Disease.- Protein Kinase C: Structure, Function and Modulation of its Catalytic Activity by Physiological and Pharmacological Agents.- The Signaling Function of Calcium and its Regulation.- PH Homeostasis and Cell Function and Disease.- The "Cytosol": a Neglected and poorly Understood Compartment of Eukaryotic Cells.- Molecular Basis of Radioprotection by Aminothiols.- Cytochrome P-450, P-448 and Lipid Peroxidation in Cell Damage.- Oxygen is a Dangerous Friend.- Free Radical Mechanisms in Tissue Injury.- Human Uricase Loss: an Evolutionary Gain Against Disease.- Cell Function and Brain Transplant.- Recovery of Function After Tissue Transplantation in the Nigrostriatal Dopamine System.- Nerve Growth Factor in vivo Actions on Cholinergic Neurons in the Adult Rat CNS.- Strategies for Improving Fetal Neuronal Integration with Adult Brain Following Brain Transplantion.- Fetal Brain Transplants Induce Recovery of Morphological and Learning Deficits of Cortical Lesioned Rats.- Cell Function and Infectious Diseases.- Oral Vaccination of Human Volunteers with qalE Mutants of Enteropathogenic Escherichia coli.- The Role of Outer Membrane Proteins from Gram-Negative Bacteria as Vaccines with Special Emphasis in Typhoid Fever. Monoclonal Antibodies Against S. Typhy porins.- Structural and Functional Modifications of Plasmodium-Infected Erythrocytes.- Inflammatory Response in Amebic Liver Abscess.- Biological Determinants of Host-Parasite Relationship in Mouse Cysticercosis Caused by Taenia crassiceps Influence of Sex, Major Histocompatibility Complex and Vaccination.- Detection of the Human Papillomavirus Genome in Cervical Cancer.- Population Dynamics of AIDS. Basic Concepts.- Structure-Based Targeting of Drugs to hiv Proteins.- On the Development of New Chemotherapeutic Agents in the Coming Decade.- New Approaches and Techniques with Potential Application to Cell Function and Disease.- Investigation of Metabolic Disorders in Patients and Animal Models Using Magnetic Resonance Spectroscopy.- Electrorotation of Blood Cells Medical Applications.- Molecular Dysfunctions in Lead Poisoning. An in vitro Model.- Molecular Basis of Contrast in MRI.- Disease Detection by MR Imaging. T1 and T2 Relaxation Times.- Magnetic Resonance Relaxation Times and Imaging in the Pathophysiology of Muscles.- Magnetic Resonance Imaging MRI of the Pituitary Gland in Sheehan's Syndrome.- Cancer Detection by Magnetic Resonance Imaging.- Treatment Evaluation of Amebic Liver Abscess by MR Imaging.- A Clinical Approach to Cell Function and Disease.- Planning the Clinical Research Protocol to Understand the Relationship Between Cell Function and Disease.- Participants.
