Introductory Perspectives.- I Laser Cooling and Manipulation of Atoms and Molecules - Atomic and Molecular Optics and Applications.- II Translational and Internal Energy Relaxation in Supersonic Free Jets, Including Possible Alignment and Condensation Phenomena.- III Photodissociation Dynamics and Electronic Spectroscopy in Molecular Beams: From Simple Molecules to Clusters and Ions.- IV Dynamics of Elementary Molecular Collisions and Femtochemistry: Theory, Real-Time Probing, and Imaging of Crossed-Beam Reactions.- V Clusters and Nanoparticles: Diffraction, Size Selection, Polarizability, and Fragmentation by Photodissociation, Electron Impact, and Atom Collision.- VI Spectroscopy and Reaction Dynamics of Molecules Isolated, Cooled (or Conditioned), by Techniques of Molecule, Cluster, Droplets, or Liquid Beams.- VII Interactions of Molecular Beams and Cluster Beams with Surfaces, and Applications.- Looking Ahead.- Author Index.