Nobody can know everything. For the successful application of techniques based on nuclear magnetic resonance to clinical problems, it is a vital necessity that individuals with widely different skills should learn a little of each others' trades by co-operation and communication. Ernest Cady has long proved himself a master of these arts to his colleagues at University College London, and by writing this excellent book he extends his experience to a wide circle of readers. Although the nuclear magnetic resonance (NMR) phenomenon had been predicted theoretically (and to some degree demonstrated experimentally) appreciably earlier, it required the advances in electronics that took place during World War II to turn NMR into a practical technique, as demonstrated independently in 1946 by Bloch and Purcell. Since then, NMR has been used extensively and increasingly by chemists and physicists. In the 1970s the first applications of NMR to animal organs yielded important advances in our knowledge of the biochemical and physiological processes as they occur in genuinely intact tissues. They showed incidentally that some conventional techniques introduce significant artifacts.
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Verlagsgruppe
Kluwer Academic Publishers Group
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
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Gewebe-Einband
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ISBN-13
978-0-306-43449-5 (9780306434495)
DOI
10.1007/978-1-4684-1333-5
Schweitzer Klassifikation
1. An Introduction to Medical Magnetic Resonance Spectroscopy.- 1.1. The Magnetic Resonance Phenomenon.- 1.2. Magnetic Resonance in a Clinical Context.- 1.3. Nuclei with Potential Clinical Applications.- 1.4. The Development of Biological MRS.- References.- 2. Fundamentals of Clinical Magnetic Resonance.- 2.1. The Origin of the Magnetic Resonance Signal.- 2.2. The Magnetic Resonance Signal.- 2.3. The Spectrum.- 2.4. The Signal-to-Noise Ratio.- References.- 3. Clinical Studies.- 3.1. Introduction.- 3.2. Studies of the Human Brain.- 3.3. Studies of Human Skeletal Muscle.- 3.4. Studies of Human Cardiac Metabolism.- 3.5. Studies of the Human Liver.- 3.6. Studies of Human Kidneys.- 3.7. Studies of Human Testes.- 3.8. In Vitro Studies of Human Body Fluids.- 3.9. Studies of Human Red Blood Cells.- References.- 4. Practical Aspects of Clinical Magnetic Resonance Spectroscopy Systems.- 4.1. An Overview of the System.- 4.2. The Magnet.- 4.3. The Spectrometer.- 4.4. Safety Requirements.- 4.5. Patient Handling.- References.- 5. Data Acquisition in Clinical Magnetic Resonance Spectroscopy.- 5.1. Fundamental Considerations.- 5.2. Signal Localization.- 5.3. Spin-Echo Techniques.- 5.4. Solvent Suppression.- 5.5. Spectral Editing.- 5.6. Absolute Quantitation.- 5.7. Measurement of Relaxation Constants.- References.- 6. Spectrum Analysis.- 6.1. Introduction.- 6.2. Measurement of the Spectrum.- 6.3. Other Analysis Methods.- 6.4. Peak Identification.- 6.5. Data Reduction.- 6.6. Testing the Analysis Methods.- References.
