This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.
This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Maße
ISBN-13
978-0-444-88051-2 (9780444880512)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Search and Discovery Methods for Novel Antimicrobials. The discovery of new bioactive microbial metabolites: screening and identification (J. Berdy). A microbial screening programme: scope and limitations (B.N. Ganguli). Microbial ecology of the phyllosphere: a source of microorganisms producing bioactive compounds (W. Fritsche). Basidiomycetes: a source for new bioactive secondary metabolites (T. Anke). Antibiotics from basidiomycetes. The 4-hydroxybenzenediazonium ion, an antimicrobial, cytotoxic and antineoplastic metabolite from the basidiomycete Agaricus xanthodermus (Agaricales) (K. Dornberger et al.). The gliding bacteria: a treasury of secondary metabolites (H. Reichenbach, G. Hofle). The metabolism of murein in bacteria: a source of bioactive compounds in the host organism (J.-V. Holtje, U. Schwarz). Approaches to new microbial metabolites with nonclassical mode of action (U. Grafe et al.). Chitin metabolism as a target for antifungal and antiparasitic drugs and agrochemicals (G.W. Gooday). Future prospects with polyene antibiotics (J. Bolard). Reports on Novel Products. Eremomycin: a new glycopeptide antibiotic (M.G. Brazhnikova et al.). Polyether antibiotics: monensins (S. Pospisil et al.). Fusicoccins: microbial synthesis, identification, physiological activity and practical application (G.S. Muromtsev et al.). Ramoplanin (A/16686): a new glycolipodepsipeptide antibiotic from actinoplanes (R. Ciabatti, B. Cavalleri). Glycopeptides: antibiotic discovery and mechanism of action (G. Cassani). Research of streptomyces producing pesticides and plant growth regulators (M. Blumauerova et al.). Regulation and Biosynthesis of Secondary Metabolites. Regulatory actions of butyrolactone autoregulators in secondary metabolite production (M. Yanagimoto). Enzymatic regulation of microbial phytoeffector biosynthesis (G. Reuter). Fermentation and biosynthesis of glycopeptide antibiotics (G.C. Lancini). Novel Developments in Antibiotic Production. Chemical modifications of the macrolide antibiotics (H. Bojarska-Dahlig). Recent advances in the enzymatic synthesis of penicillins (J.M. Luengo). Biotransformation of azacarbazoles as a means of developing novel antineoplastic compounds (W. Peczynska-Czoch et al.). Resistance and Mode of Action Studies. Streptothricin resistance (H. Krugel et al.). Resistance against nourseothricin (streptothricin) of Escherichia coli strains: biochemical aspects (G. Seltmann). Elucidication of the molecular mechanisms of action of some potential antitumor drugs. A contribution by infrared studies of their DNA complexes (H. Fritzsche, A. Rupprecht). Protease inhibitors and biological control (T. Aoyagi). Author Index.
