Introduction to mass spectrometry/mass spectrometry - history of mass spectrometry/mass spectrometry, concepts and principles, nomenclature; MS/MS instrumentation - principles of charged-particle analysis, sector-based MS/MS instruments, quadrupole instruments, hybrid instruments, MS/MS with ion-trapping techniques, reaction regions; reactions in MS/MS - unimolecular dissociation, activation reactions reactive collisions, charge permutation reactions; applications of MS/MS to fundamental studies - ion structures, reaction meachanisms, thermochemistry; characteristics of MS/MS for analytical applications - sample considertions, choice of ionization method, interpretation of MS/MS spectra; analytical applications - environmental applications, natural products applications, industrial products applications, foods and flavours applications, forensic chemistry applications, petroleum and petroleum products applications, bioorganic applications, pharmaceutical applications, applications to continuos flow samples and processes; conclusions and outlook - instrumentation in MS/MS, outlook for advanced applications, interpretation of MS/MS data, conclusions. Appendices: MS/MS scan modes on various instrument configurations; frequently used symbols and acronyms.
