Overview of immunotoxicology; predictive value of immunotoxicological evaluation of therapeutics in the assessment of risk; good laboratory practices in immunotoxicology; ELISA assay to assess humoral immunity; CTL; popliteal lymph node assay; flow cytometry evaluations in man, mouse, rat, primates and dogs; interleukins 1, 2, 3 and 6; molecular probes for IL-1; interferon assay; acute phase proteins; the use of immunohistochemistry for immunotoxicology; in vitro approaches to evaluate deficits in B lymphocyte.