The Beauty of Protein Structures and the Mathematics behind Structural Bioinformatics
Providing the framework for a one-semester undergraduate course, Structural Bioinformatics: An Algorithmic Approach shows how to apply key algorithms to solve problems related to macromolecular structure.
Helps Students Go Further in Their Study of Structural Biology
Following some introductory material in the first few chapters, the text solves the longest common subsequence problem using dynamic programming and explains the science models for the Nussinov and MFOLD algorithms. It then reviews sequence alignment, along with the basic mathematical calculations needed for measuring the geometric properties of macromolecules. After looking at how coordinate transformations facilitate the translation and rotation of molecules in a 3D space, the author introduces structural comparison techniques, superposition algorithms, and algorithms that compare relationships within a protein. The final chapter explores how regression and classification are becoming more useful in protein analysis and drug design.
At the Crossroads of Biology, Mathematics, and Computer Science
Connecting biology, mathematics, and computer science, this practical text presents various bioinformatics topics and problems within a scientific methodology that emphasizes nature (the source of empirical observations), science (the mathematical modeling of the natural process), and computation (the science of calculating predictions and mathematical objects based on mathematical models).
Rezensionen / Stimmen
... the book presents a number of topics in structural bioinformatics, aiming to emphasize the beauty of the area as well as some of the main problems. It targets advanced undergraduate students and hence the description of more complicated algorithms is avoided. It nevertheless provides an interesting introduction to the area.
-Lucian Ilie, Mathematical Reviews, Issue 2009k
Reihe
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Undergraduate
Illustrationen
124 s/w Abbildungen, 24 farbige Abbildungen, 6 s/w Tabellen
6 Tables, black and white; 24 Illustrations, color; 124 Illustrations, black and white
Maße
Höhe: 229 mm
Breite: 152 mm
Gewicht
ISBN-13
978-1-58488-683-9 (9781584886839)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
University of Waterloo, Ontario, Canada
Autor*in
University of Waterloo, Ontario, Canada
Preface. The Study of Structural Bioinformatics. Introduction to Macromolecular Structure. Data Sources, Formats, and Applications. Dynamic Programming. RNA Secondary Structure Prediction. Protein Sequence Alignment. Protein Geometry. Coordinate Transformations. Structure Comparison, Alignment, and Superposition. Machine Learning. Overview of the Appendices. Index.
