This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson's disease, Alzheimer's disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.
Rezensionen / Stimmen
"This is an authoritative and thorough overview of a field of growing significance to neuroscience. Metal ion metabolism is intimately involved with the causes of most neurodegenerative disease, and is an area of unexploited importance for potential drug development. This work is timely, and tremendously useful with an excellent choice of subjects, beautifully and rigorously presented"
-Prof. Ashley I. Bush - University of Melbourne, Australia
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Experts (biologists and chemists) working in the fields of metallochemistry or neurodegeneration; university students pursuing specialist courses relating to these fields.
Illustrationen
12 page insert prints 4-color and goes at END OF BOOK
23 Illustrations, color; 43 Illustrations, black and white
Maße
Höhe: 229 mm
Breite: 152 mm
Gewicht
ISBN-13
978-981-4316-01-9 (9789814316019)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
1. Introduction, 2. A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease, 3. Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration, 4. Mammalian Metallothioneins, 5. Copper Transporting P-Type ATPases in the Brain, 6. Role of the Amyloid Precursor Protein and Copper in Alzheimer's Disease, 7. Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer's Disease, 8. Prion Diseases, Metals and Antioxidants, 9. Emerging Role for Copper-Bound ?-Synuclein in Parkinson's Disease Etiology, 10. Interactions of ?-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson's Disease, 11. An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective, Index
