The field of molecular genetics is undergoing an explosion, not only in its fundamental understanding of the genetic processes but also in the potential applications as research tools and therapeutic approaches to many disease areas. Mental disorders are no exception and it is likely that most new psychotropic drugs will in future be derived through molecular genetic approaches. This book examines the place of molecular genetics in our understanding of the basic mechanisms of mental disorders and their role in highlighting new drug targets.
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
40 s/w Abbildungen
40 Illustrations, black and white
Maße
Höhe: 235 mm
Breite: 187 mm
Gewicht
ISBN-13
978-1-85317-917-4 (9781853179174)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Autor*in
Pierre Fabre Medicament, Castres Cedex, France
1. Characterization of Expression Profiles of Genes Involved in Brain Functions by Quantitative Hybridization of High-Density DNA Arrays 2. Differential Display for Detecting Potential Gene Candidates 3. Molecular Psychopharmacology as a Prelude to a Molecular Psychopathology of Affective Disorders: The Significance of Differential Display Methodology to Study Programs of Gene Expression 4. Diverse Signalling Via a 5. The Knockout Mouse: Pharmacological Tool or Model of Psychiatric Disorder 6. The Orphan Receptor Strategy and the Discovery of Novel Neuropeptides 7. Antisense: A Genetic Approach to Depression 8. Characterization of 5-HT-Moduline Through an Integrated Use of Molecular Genetic Tools 9. Validation of the a 10. Acetylcholinesterase Variants in Mammalian Stress: Catalytic Short-Term and Structural Long-Term Roles 11. Modification of Gene Expression in the Mechanism of Action of Antipsychotic Drugs 12. Regulation of Neural Plasticity by Stress and Antidepressant Treatment 13. Genetic Variation and Alternative Splicing of 5-HT Receptors : Potential Role in Neuropsychiatric Diseases and Modification of Pharmacolog ical and Functional Properties 14. Polymorphisms of the Enzymes Involved in Monoamine Synthesis 15. Serotonin Transporter: From Genomics and Knockouts to Behavioral Traits and Psychiatric Disorders 16. Transcription Factors in the Development of the Mesencephalic Dopamine System 17. Pharmacogenomics of Schizophrenia 18. Relationship Between ApolipoproteinE and Susceptibility to Neurodegenerative Disease
