Part 1 Epidemiology: impact of changing patterns of dental caries, Martin Downer; caries in our aging population - what are we learning, Paul Depaola; caries in young populations worldwide, Ken Stephen; are we using epidemiology effectively?, Dennis O'Mullane. Part 2 Saliva: molecular biological approaches to caries - role of saliva, Lawrence Tabak; hydroxyapatite-interactive proteins, Donald Hay; salivary mucins and dental plaque formation, Michael Levine; human salivary pellicle glycoproteins - identification and bacterial receptor activity, Susan Fisher; salivary antimicrobials - where are we?, Frank Oppenheim; ebb and flow of the salivary tide, Colin Dawes. Part 3 Teeth: enamel and dentine gene expression and caries resistance, Harold Slavkin; structure and composition of cementum, Martha Somerman; enamel-plaque fluid interactions, Henry Margolis; physical chemical aspects of the mineralization and demineralization of tooth components, George Nancollas; relationship of the in vitro studies to clinical problems, Dorothy Geddes. Part 4 Clinical studies: caries risk assessment, John Stamm; salivary flow and dental caries in aging adults, Ronald Billings; caries in renal dialysis patients, Cyril Meyerowitz; determinants of virulence in dental plaque, J. Hans van Houte; alternatives for conventional clinical caries trials, David Banting. Part 5 Microbiology, plaque: adhesion and cohesion of plaque microflora - a function of microbial fimbriae and fibrils?, Arnold Bleiweis; molecular biology of streptococcus mutans virulence, Howard Kuramitsu; arginine deiminase and alkali generation in plaque, Robert Marquis; ecological determinants in dental root surface caries, Richard Ellen; adaptations in dental plaque, Domenick Zero; oral ecological disasters - the role of short-term extracellular storage polysaccharides, Robert Burne. Part 6 Diet, nutrition, prevention: effects of diet and nutrition on saliva composition, Dorothea Jonson; sweeteners and caries - some emerging lessons, Jason Tanzer; genetic manipulation of the oral streptococci, Robert Quivey; enhancing effects of fluoride, Jan Ekstrand; promoting the disposition of acid in plaque, George Bowden; vaccination - a cariostatic option?, Martin Taubman.