Volume 1 provides the reader with a basic overview of the field of toxicology. The volume is divided into four sections: 1) introduction, 2) toxicokinetics, 3) mechanisms of toxicity, and 4) risk assessment. The volume provides an in-depth coverage of the field of toxicokinetics including exposure assessment, routes of exposure of toxicants, and distribution, biotransformation, and excretion of toxicant. Dosimetry modeling, including physiologically based pharmacokinetic models, and extrapolation modeling are covered. The volume also covers key mechanisms associated with toxicity/carcinogenicity of chemicals. Concepts of risk assessment are also discussed in this volume. The contents of Volume 1 lays the ground work for subsequent volumes of the Comprehensive Toxicology series where different aspects of the field of toxicology are extensively discussed.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Illustrationen
Gewicht
ISBN-13
978-0-08-042966-3 (9780080429663)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Autor*in
Chemical Industry Institute of Toxicology, Research Triangle Park, NC, USA
Introduction to the principles of toxicology (D.L. Eaton, E.P. Gallagher). Exposure analysis and its assessment (P.J. Lioy). Toxicokinetics: oral exposure and absorption of toxicants (C.T. Walsh). Toxicokinetics: inhalation exposure and absorption of toxicants (M.A. Medinsky, P.M. Schlosser, B. Asgarian). Toxicokinetics: dermal exposure and absorption of toxicants (R.C. Wester, H.I. Maibach). Toxicokinetics: distribution of toxicants (E.J. O'Flaherty). Toxicokinetics: biotransformation of toxicants (G.L. Kedderis). Toxicokinetics: routes of elimination (D.E. Rickert). Toxicokinetics: concepts of dose (A.R. Dahl). Toxicokinetics: modeling disposition (G. Johanson). Toxicologic interactions of chemical mixtures (R.S.H. Yang). Experimental models for the investigation of toxicological mechanisms (D. Acosta, R.L. Grant, M.A. Smith). Cytolethality: necrosis vs. apoptosis (M. Treinen Moslen, A. Badakumaran). Mitogenesis (R.C. Cattley, B.G. Lake). The calcium messenger system (J.G. Pounds, M.J. McCabe). Mechanisms: free radicals and reactive oxygen species (J.P. Kehrer). DNA-reactive agents (A. Dipple). Risk assessment (J.V. Rodricks).
