Based on a very successful handbook as well as student lectures given by the author, this textbook comprehensively covers the theory, methods and applications of protein engineering and biocatalysis. The author is well known due to his strong background in industry as well as academia, and has extensive teaching experience in Europe and North America. From the contents: Basics Handling of enzyme biocatalysts Protein engineering Stabilization and retention of biocatalysts Applications Specialties Of interest to a wide audience of (bio)chemists and bioengineers.
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
32 farbige Abbildungen, 250 s/w Abbildungen
Maße
Höhe: 240 mm
Breite: 170 mm
ISBN-13
978-3-527-31868-1 (9783527318681)
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Schweitzer Klassifikation
Andreas Bommarius is currently professor at the Georgia Institute of Technology in Atlanta, GA, USA, both at the School of Chemical & Biomolecular Engineering and at the School of Chemistry & Biochemistry. He obtained his diploma in Chemistry from the Technical University in Munich, Germany (1984) and his PhD in Chemical Engineering at MIT in Cambridge, MA (1989). From 1990-2000, he headed the Enzyme Catalysis lab and pilot plant of Degussa in Hanau, Germany. His research interests focus on biocatalysis and bioprocessing, more specifically on the developments of novel biocatalysts, protein stability, and data-driven protein engineering. Dr. Bettina Riebel-Bommarius is a research scientist in the Department of Pathology at Emory University in Atlanta, GA, USA. After obtaining her diploma in Biology at the University of Cologne, Germany and her PhD in Biochemistry and Enzyme Technologies at the University of Dusseldorf, Germany, she was a postdoctoral fellow at the Research Center in Julich, Germany and at Roche Diagnostics in Penzberg, Germany. In 2000, she moved to her current position in Atlanta, GA. Her research interests are focused on the biochemical and molecular interactions between host and pathogen involving tyrosine phosphorylation. The authors published previously a very successful handbook on the same topic.
I. basics 1. key features of biocatalysis; comparison with other catalysts 2. protein biochemistry: protein folding, enzyme mechanisms 3. activity, selectivity, and stability of protein biocatalysts II. handling of enzyme biocatalysts 4. isolation and purification 5. kinetics 6. enzyme reactors III. protein engineering 7. rational methods 8. combinatorial methods 9. data-driven methods IV. stabilization and retention of biocatalysts 10. formulation in aqueous systems 11. immobilization on solid support 12. enzymes in organic solvents and other nonaqueous media V. applications 13. enzymes as products: detergents, textiles, pulp and paper, animal feed 14. enzymes as catalysts: chiral intermediates, active pharma ingredients 15. enzymes as components in fermentation systems: biofuels, pharma compounds VI. specialities 16. evolution and creation of novel enzyme activities 17. artificial protein catalysts 18. metabolic engineering
