Section 1: Introduction.
Introduction to hematotoxicology (J.C. Bloom). Hematopoiesis: Structure-Function relationships in bone marrow and spleen (K.M. Young, L. Weiss).
Section 2: The Erythron.
Evaluation of red cells and erythropoiesis (W. Fried). Nonimmune hemolysis and toxic methemorglobinemia (M.B. Dabrow, T.G. Gabuzda). Drug-induced immune hemolytic anemia (A. Salama). Toxic effects on erythrogenesis (R.T. Means Jr). Comparative biology and toxicology of the erythron (J.E. Smith).
Section 3: The Leukon.
Evaluation of granulocytes and mononuclear phagocytes (J.L. Liesveld, M.A. Lichtman). Response of granulocytes to toxic injury (A.V. Pisciotta). Evaluation of lymphoid cells and response to toxic injury (J.B. Margolick, A.D. Donnenberg). Leukemogenesis as a toxic response (R.D. Irons). Comparative leukocyte biology and toxicology (V.E.O. Valli, J.P. McGrath).
Section 4: Hemostasis.
Overview of hemostatic mechanisms (J.B. Lawrence). Evaluation of platelets and thrombopoiesis (P. Badenhorst, H.F. Kotze). Modulation of platelet function by xenobiotics: toxicologic implications (J.A. Jakubowski). Response of thrombocytes to toxic injury (R.H. Aster). Modulation of coagulation and fibrinolytic systems by therapeutic and nontherapeutic agents (T.W. Love, W.F. Novotny).
Section 5: Risk Assessment.
Human hematopoietic stem cells: laboratory assessment and response to toxic injury (R.E. Parchment, M.J. Murphy Jr). Analysis and risk assessment of hematological data from clinical trials (A. Szarfman, L. Talarico, J.G. Levine). Preclinical risk assessment for hematotoxicity: animal models and in vitro systems (A. Deldar, R.E. Parchment). Evaluation and interpretation of hematologic data in preclinical toxicology (R.L. Hall).
